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《中山医科大学学报》 1991-01
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COMPARISON OF RANITIDINE AND COLLOIDAL BISMUTHATE IN THE TREATMENT OF GASTRIC ULCER; A SINGLE-BLIND RANDOM TRIAL

Cui Yi Kuang Heling Zhang Tianyu Hu Pinjin Lin Lili Huang Riyun ( Department of Internal Medicine, First Affiliated Hospital ) Lin Hanliang ( Department of Pathology )  
Fifty-five patients with benign gastric ulcer (GU) proved by endoscopy were randomly divided into ranitidine and De-Nol groups. The healing rates at six weeks were 71.4% and 70.4%. respectively(P0.05). No obvious side effects of both medicines were found. The result showed that De-Nol can be the alternative to ranitidine for treating GU. Cam-Pylobacter pylori(CP) detected by Warthin-starry silver stains in antral mucosa was found in 52 of the 55 patients(96.2%) with GU which was higher than in 23 of the 30(76.5%) with chronic gastritis(P0.05). The presence of CP before and after the treatment with De-Nol were 96.3%. 65.4%, respectively (P0.01). This result showed the bactericidal effect of De-Nol. No significant relationship was found between the presence of CP and gastritic activity.
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