THE DISTRIBUTION OF TOPOISOMERASES ACTIVITIES IN NOMAL HUMAN TISSUES AND THE CORRELATION WITH THOSE IN TUMOR TISSUES
Chai Qing Wang Likai Xu Xiaoli (Department of Biochemistry)
DNA toposicmerases have been found to have an important role in genetic events. In order to explore the biological function of the enzymes, authors studied the distribution and specific activities of DNA topoisomerases in some organs of the human body and their malignant tissues; and discovered that the activities of DNA topoisomerase Ⅰ and Ⅱ existed in all of human organs and their malignant tissues including liver, lungs, kidney, stomach, brain, bladder, thyroid, prostate, testicle. There was no significant difference of the activities of DNA toposiomerase Ⅰ between normal tissues and malignant tissues except testicle in which the activities of DNA topoisomerase Ⅰ and Ⅱ were higher than those of other tissues. The specific activities of DNA topoisomerase I were much higher in malignant tissues than those in normal tissues.