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《Journal of Sun Yat-sen University (Medical Sciences)》 1993-01
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Wen Yanping Liang Guishang (Department of Obstetrics and Gynecology First Affiliated Hospital)  
This study comprised of 180 normal pregnancies and 8 patients with prolactinoma who became pregnant after CB-154 treatment. The results are as follows: 1) Serum PRL in both groups was gradually elevated till the third trimester gestation. The PRL concentrations were significantly higher in prolactinoma group than those in normal group during 6th-l6th weeks of gestation. 2) Serum E2 levels increased with developing of gestation "and no statistical differences were observed between the two groups. 3) Significant correlations were found between serum PRL, E2 levels and the weeks of gestation, respectively. 4) The correlation between serum PRL and E2 concentration was significant only in the second trimester of normal group whereas it was significant in first trimester in prolactinoma group. These results suggested that serum PRL and E2 concentrations were increasing gradually during the whole period of gestation, but their correlation was significant only in some stages of gestation. It seems that E2 was the main stimulator of PRL-secretion, however it was not the only modulator during pregnancy. That the serum levels of PRL and E2 showed no remarkable differences between two groups indicats that prolactinoma does not affect E2-production in the placental and that PRL secretion is autonomous. Hence, we deduce that women with prolactinoma would be well being during their pregnancy and that periodic PRL assay is one of the reliable monitoring index.
【Fund】: 国家自然科学基金;; 部分863高技术科学基金资助项目
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