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The Acute Effects of Talc Slurry Pleurodesis in Rabbit Model

XIE Can mao 1,Richard W. Light 2 (1.Department of Medicine, First Affiliated Hospital, Guangzhou 510080,China; 2. Saint Thomas Hospital, Nashville, TN 37202)$$$$  
Objective To study the acute effects of talc instillation intrapleurally. Methods 50 New Zealand white male rabbits were divided into 5 groups according to the study period of 6 hours, 1,2,4 and 7 days after instillation. 10 rabbits received saline intrapleurally as control. Results The pleural fluid was almost absorbed in control on day 1, however, the exudative fluid reach its peak on day 4 and completely disappeared on day 7 after instillation in talc groups. WBC was obviously increase, neutrophils were prominent on day 1 and after then the lymphocytes dominated. The levels of LDH increased rapidly and reached its peak on day 2. The pleural adhesions formed at 6 hour and significantly increased after day 4. Pleural inflammation microscopically was the most obvious on day 2 and fibrosis on day 7. Conclusion Talc slurry induces acute pleural inflammation and is a safe, effective sclerosant. It seems not necessary to drain after instillation.
【CateGory Index】: R561
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