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《ACADEMIC JOURNAL OF SUN YAT-SEN UNIVERSITY OF MEDICAL SCIENCES》 2000-01
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Expression of HLA DR on Alveolar Macrophages from Patients with Lung Cancer

ZHOU Feng li, LI Guo ben, TANG Ying chun (Department of Respiratory, Third Affiliated Hospital, Sun Yat sen University of Medical Sciences, Guangzhou 510630,China)$$$$  
Objective To observe the expression of human leukocyte antigen DR (HLA DR) on alveolar macrophages. Methods The alveolar macrophages obtained by bronchoalveolar lavage, were separated and incubated. The expression of HLA DR was detected and the positive rates of alveolar macrophages were compared. Results ①Alveolar macrophages from all cases express HLA DR without stimulation. The positive rate of alveolar macrophages was higher from patients with lung cancer than that from cases with nonmalignant pulmonary diseases. ② Expression of HLA DR in case after stimulation with IFN α or LPS were higher than that wihtout stimulation, and stimulation with IFN α and LPS in combination was the highest. ③Whether stimulated or not, the positive rate of alveolar macrophages from the tumor bearing side of lung was higher than that from the nontumor bearing side of lung. Conclusion The funtion that alveolar macrophages submit antigen was enganced, because the alveolar macrophages aroud the tumor express HLA DR. The function that alveolar macrophages submit antigen was enhanced after stimulated with IFN α or/and LPS, and the effection of IFN α and LPS was cooperative.
【CateGory Index】: R734.2
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