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《ACADEMIC JOURNAL OF SUN YAT-SEN UNIVERSITY OF MEDICAL SCIENCES》 2000-01
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Changes of Serum HBV DNA level of Disease Reactivations in Patients with Chronic Hepatitis B

ZHOU Xiao hui 1, GAO Zhi liang 2, YAO Ji lu 2 (1.Department of Infectious Diseases, The Second Affiliated Hospital, Shantou University Medical College, Shantou, 510031 2.Department of Infectious Diseases, The Third Affiliated Hospital, Sun Yat s  
Objective We study the changes of HBV DNA serum level in acute hepatic exacerbation of the disease in chronic hepatitis B patients. Methods The serum HBV DNA concentration in 60 patients with acute exacerbation (AE) of chronic hepatitis B were tested by the quantitative PCR using the AmpliSensor assay. Results In 60 patients with CHB (38 HBeAg positive and 22 anti HBe positive), levers of the serum HBV DNA in sera were higher during acute attacks than the one during recovery (P0 05); No correlation were found among the levels of HBV DNA, alanine aminotransferase(ALT), aspartate aminotransferase (AST) and total bilirubin. Conclusions This investigation revealed there was significant correlation between the increasing levels of serum HBV DNA and the reactivations of patients in chronic hepatitis B. The increases in viral replication and subsequent host immune response to virus infected hepatocytes play an important role in initiating reactivation of patients with CHB.
【Fund】: 卫生部优秀青年人才基金! (970 1 8);;美国中华医学基金
【CateGory Index】: R512,62;R373.2
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