Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Sun Yat-sen University (Medical Sciences)》 2005-01
Add to Favorite Get Latest Update

Association of Macrophage Migration Inhibitory Factor with Tumor Neovascularization and Lymph Node Metastasis of Nasopharyngeal Carcinoma

LI Zhi 1, LIN Su-xia 2, LIANG Hui-zhen 1, LIANG Ying-jie 1, HE Jie-hua 2(1. Department of Pathology, Zhongshan Medical College, SUN Yat-sen University, Guangzhou 510080, China; 2. Department of Pathology, Cancer Center, SUN Yat-sen University, Guangzhou 510060, China)  
To detect the expression of macrophage migration inhibitory factor (MIF) and vascular endothelial growth factor (VEGF) in nasopharyngeal carcinoma (NPC), and correlate their expression level with intratumoral microvessel density (IMD) to investigate the mechanism of invasion and metastasis of NPC cells. Forty-five NPC biopsies were collected from the patients with NPC during 1999-2003. Immunohistochemical staining was used for detecting the expression of MIF, VEGF in NPC tissues. The number of IMD was evaluated by counting the CD34-positive neovessels in the most active areas of tumor neovascularization or hotspots. The associations of these indexes with pathological and clinical features were statistically analyzed. The positive expression rates of MIF and VEGF were 78% (35/45) and 71% (32/45), respectively. The expression of MIF showed a correlation with lymph node metastasis. The higher expression of MIF were always found in NPC neoplastic cells with cervical lymph node metastasis than that in NPC without lymph node metastasis (P =0.029). The number of IMD in tumor with metastasis was also significantly higher than that without lymph node metastasis (P =0.026). Meanwhile, the number of IMD counted in MIF positive group (35.1±13.3/HPF) was significantly higher than that in MIF negative group (20.9/HPF±10.2/HPF), P value was 0.003. In addition, the expression of MIF in NPC neoplastic cells with Schmincke growth pattern (67.4%±35.2%) was higher than that in NPC with Regaud growth pattern (32.9%±29.7%), there existed a significantly difference in MIF expression of NPC between two growth patterns (P =0.007). There were positive correlations found for the expression of MIF with VEGF and IMD counting, respectively (P 0.05). However, there was no relationship found in the expression of VEGF with the other clinicalopathological features of NPCs including age, gender, histopathological type, and clinical stage. [Conclusion]MIF cytokine might play an important promoting role in contributing the metastasis of NPC as well as associated with tumor neovascularization and up-regulating the VEGF expression of NPC.
【Fund】: 国家自然科学基金资助项目(30200254);; 广东省自然科学基金资助项目(031672)
【CateGory Index】: R739.63
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 7 Hits
1 LI Guo-qing,LIU Yan-ping,FENG Xia,et al.Department of Gastroenterology,the Second Affiliated Hospital of Nanhua University,Hengyang(421001),China;Effects of macrophage migration inhibitory factor on the proliferation and expression of angiogenesis factor in human colon carcinoma cell HT-29[J];International Journal of Digestive Diseases;2008-06
2 DAI Taiming,MA Hong,SONG Yufeng,FENG Hongchao,WEI Honglin(Department of Oral and Maxillofacial Surgery,The Affiliated hospital of Guiyang Medical College,Guiyang 550004,China);The Expression of Macrophage Migration Inhibitory Factor in Oral Squamous Cell Carcinoma and Its Significance[J];Journal of Guiyang Medical College;2007-04
3 YI Wei,XIA Yun-fei Department of Radiation Oncology,Sun Yat-Sen University Cancer Center,Guangzhou 510060,P.R.China;Biological research on nasopharyngeal carcinoma lymphatic metastasis[J];Chinese Journal of Cancer Prevention and Treatment;2007-22
4 SHAN Zhi-xin, YU Xi-yong, LIN Qiu-xiong, DENG Chun-yu, LIU Yuan, CAI Shi-xia, TAN Hong-hong, FU Yong-heng, LIN Shu-guang (Research Center of Medical Sciences, Guangdong Provincial People's Hospital, Guangzhou 510080, China);Role of Human Macrophage Migration Inhibitory Factor in Promoting Genes Expression Involved in Angiogenesis[J];Journal of Sun Yat-sen University (Medical Sciences);2005-06
5 LIN Qu1, HUANG Ming-sheng2, WEN Jing-yun1, DONG Min1, WANG Qing-ming1, WU Xiang-yuan1 ( 1. Department of Oncology; 2. Department of Radiology, The Third Affiliated Hospital of SUN Yat-sen University, Guangzhou 510630, China );Serum Levels of Macrophage Migration Inhibitory Factor in Patients with Hepatocellular Carcinoma and Its Clinical Significance[J];Journal of Sun Yat-Sen University(Medical Sciences);2007-02
6 TIAN Li, LIU Li-zhi, FAN Wei-jun* (Medical Imaging and Interventional Radiology Center, The State Key Laboratory of Oncology in Southern China / / Cancer Center, SUN Yat-sen University, Guangzhou 510060, China);Correlation of Parameters of Dynamic Contrast Enhanced MRI with MVD and Expression of VEGF in Nasopharyngeal Carcinoma[J];Journal of Sun Yat-Sen University(Medical Sciences);2009-03
7 XIA Xiao-Ai,HE Cheng-Zhang,LV Bei,et al The People's Hospital of Wuxi,Wuxi 214062,JiangSu,China;Expression of migration inhibitory factor in ovarian carcinoma and the correlation with microvessel density[J];Maternal and Child Health Care of China;2009-26
【Citations】
Chinese Journal Full-text Database 3 Hits
1 LI Zhi, ZONG Yongsheng. Department of Pathology, Sun Yat sen University of Medical Sciences, Guangzhou 510089;Effects of LMP 1 expression on neoplastic cell proliferation and apoptosis in nasopharyngeal carcinoma[J];CHINESE JOURNAL OF PATHOLOGY;1999-05
2 LI Zhi(Email:pathol@gzsums.edu.cn), LIN Su-xia, LIANG Ying-jie.Department of Pathology, Sun Yat-sen Medical College, Sun Yat-sen University,Guangzhou 510089,China;Increased cell migration of nasopharyngeal carcinoma cell lines in vitro by macrophage migration inhibitory factor[J];Chinese Journal of Pathology;2004-01
3 LIN Suxia 1 , ZONG Yongsheng 2* , LIN Hanliang 2 , et al. (1. Department of Pathology, Affiliated Tumor Hospital, Sun Yat-sen University 510060, Guangzhou; 2. Department of Pathology, Sun Yat-sen Medical College, Sun Yat-sen University, Guangzhou);Effects of Epstein-Barr virus LMP1 on neoplastic cell differentiation in nasopharyngeal carcinoma[J];Tumor;2003-02
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 ZONG Yong sheng1, ZHONG Bi ling1, LIANG Ying jie1, ZHANG Min1, LIN Su xia2,He Jie hua2, LIANG Xiao man2, WU Qiu liang2, ZENG Yi xing2*1.Department of Pathology,Sun Yat sen Medical College,Sun Yat sen University,Guangzhou 510089,P.R.China2.Tumour;Advancement of Studying the Biological Characteristics of Nasopharyngeal Carcinogenesis[J];Chinese Journal of Cancer;2002-06
2 WANG Cheng-xing1,REN Wei2,LI Xiao-y an2,GU Huan-hua2,YI Wei2,WENG Xin -xian2,XIA Lin-qing2,DENG Xi-yun2,C AO Ya2 (1Oral and Maxillofacial Surgery, Xiangya Hospital,Central Southern University,Changsha 410078,China;2 Institute of Oncology,Xiangya Med ical College,Central Southern Uni versity,Changsha 410078,China);The LMP1 CTAR1 or LMP1 CTAR2 of Ep stein-Barr Virus Promotes Prolifer ation of Human HNE2 Cell Line[J];Chinese Journal of Virology;2003-03
3 Hong-Mei Wu,1,2 Sen-Lin Zhu,3 Long-Jun He,3 Yan-Hui Liu4 and Dan Xie1,21.State Key Laboratory of Oncology in South China,Guangzhou,Guangdong,510060,P.R.China.2.Cancer Research Institute,Sun Yat-sen University Cancer Center,Guangzhou,Guangdong,510060,P.R.China.3.Department of Medical,The First Affiliated Hospital,Sun Yat-sen University,Guangzhou,Guangdong,510080,P.R.China.4.Department of Pathology,Guangdong Provincial People's Hospital,Guangzhou,Guangdong,510080,P.R.China.;Clinical significance of macrophage migration inhibitory factor in invasion of ovarian cancer[J];Chinese Journal of Cancer;2009-10
4 YU Chang1,XIONG Yongyan21Dept.of Pathology,Zhejiang Cancer Hospital,Hangzhou 310022,China2Dept.of Pathology,Zhongnan Hospital of Wuhan University,Wuhan 430071,China;Expression and Clinical Significance of MIF,CD147,and MMP-9 in Hepatocellular Carcinoma[J];Medical Journal of Wuhan University;2009-03
5 PANG Guo-fu,LI Jie-fang,DING ping,et al (The First Affiliated Hospital of Nanhua University,Hengyang,Hunan 421001,China);The Expression of p53 and MIF in Human Prostatic Carcinoma and Their Clinical Significances[J];Journal of Nanhua University(Medical Edition);2008-04
6 BAI Weiqi1 TANG Jianguo2 (1Department of Otolaryngology,the Second Hospital of Ningbo City,Ningbo,315010,China;2Department of Otolaryngology-Head and Neck Surgery,the Affiliated Sir Run Run Shaw Hospital of Zhejiang University);The expression and relationship of cyclooxygenase-2 and latent membrane protein-1 in nasopharyngeal carcinoma[J];Journal of Clinical Otorhinolaryngology Head and Neck Surgery;2009-03
7 Yao Min, Liu Qiang, Gu Yongping, Pan Jun (Department of Pathology, Suzhou University Medical School, Suzhou 215007);Relationship of apoptosis to cytotoxic lymphocytes and LMP-1 expression in nasopharyngeal carcinoma[J];Chinese Journal of Clinical and Experimental Patholog;2001-06
8 Li Zhi, Lin Suxia, Liang Huizhen, He Jiehua (Department of Pathology, Sun Yat-sen Medical College, Sun Yat-sen University, Guangzhou 510089);Expression of macrophage migration inhibitory factor, MMP-2 and MMP-9 in nasopharyngeal carcinoma[J];Chinese Journal of Clinical and Experimental Pathology;2004-02
9 LI Zhi~1, LIN Su-xia~2, LIANG Hui-zhen~1, et al(1.Department of Pathology, Sun Yat-sen Medical College, Sun Yat-sen University, Guangzhou, 510089, China; 2.Department of Pathology, Cancer Center of Sun Yat-sen University, Guangzhou, 510089, China);Expression of macrophage migration inhibitory factor (MIF) and hepatocyte growth factor (HGF) in nasopharyngeal carcinoma andits relation to clinical prognosis[J];Journal of Practical Oncology;2005-04
10 Chu Hanqi, Xiong Hao, Jamal Alhosam et al Department of Otolaryngology, Institute of Otolaryngology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030;Expression of LMP-1 in Nasopharyngeal Cancer Tissue and Its Relation with Peripheral Blood EBV-IgA/VCA[J];Acta Medicinae Universitatis Scientiae et Technologiae Huazhong;2008-04
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Li Zhi, Lin Su Xia, Liang Ying Jie, Zong Yong Sheng Department of Pathology, Sun Yat sen Medical College, Sun Yat sen University, Guangzhou,Guangdong,510089, P.R.China;Effect of Macrophage Migration Inhibitory Factor (MIF) on Expression of MMP-2,MMP-9,and IL-8 in Nasopharyngeal Carcinoma Cell Strains[J];Chinese Journal of Cancer;2004-02
2 PAN Jin hong, JIN Xi yu, SONG Bo, XIONG En qing (Urinary Surgery Research Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, China);Effects of E-cadherin gene transfection on bladder cancer cell growth and invasion[J];Acta Academiae Medicinae Militaris Tertiae;2004-04
3 SHI Ji Hong, ZHAO Yong Tong, WANG Jun Lou, HAN Wei, YAN Zhen, ZHANG Ying Qi Biotechnology Centre, Fourth Military Medical University, Xi'an 710033, China;Analysis of low molecular peptides by sodium dodecyl sulfate polyacrylamide gel electrophoresis[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;2000-06
4 JIN Zhi-qing, ZHI Fa-chao, CHEN Xue-qing, WANG Ya-dongInstitute for Digestive Disease of PLA, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China;Expression of macrophage migration inhibition factor in pancreatic carcinoma tissue[J];Journal of First Military Medical University;2004-11
5 Mo Wuning; Huang Guangwu; Kuang Guoqian (Fist Affiliated Hospital, Guangxi Medical University, Nanning 530021 );EXPRESSION AND SIGNIFICANCE OF nm23-H_1 PROTEIN IN NASOPHARYNGEAL CARCINOMA[J];JOURNAL OF GUANGXI MEDICAL UNIVERSITY;1999-01
6 MA Hong,FENG Hong-chao,LIU Rui(Department of oral-Maxillofacial Surgery,The Affiliated Hospital of Guiyang Medical College,Guiyang 550004,China);Statistical Analysis on Pathology of 721 cases of Neoplasm in Oral-Maxillofacial Region[J];Journal of Guiyang Medical College;2005-05
7 Zeng Jun,Gong Lingling,Cheng Xiao,et al Department of Pathology,Second Affiliated Hospital,Hubei Medical University,Wuhan 430071,China;The Correlation of Microvessel Density,Vascular Endothelial Growth Factors and P53 with Prognosis in Nasopharyngeal Carcinoma[J];JOURNAL OF HUBEI MEDICAL UNIVERSITY;2000-03
8 LUO Jun li, XIAO Jian yun, TIAN Yong quan, et al Department of Otolaryngology, Xiangya Hospital, Hunan Medical University(Changsha 410008);MDM2 gene amplification and overexpression in nasopharyngeal carcinoma[J];BULLETIN OF HUNAN MEDICAL UNIVERSITY;2000-01
9 CHENG Qing 1 LIU Gonghan 1 WU Zhanyuan 1 WU Yuzhen 1 XIAO Bokui 1 ( 1 Department of Otolaryngology Head and Neck Surgery,People′s Hospital of Wuhan University, Wuhan 430060);Bcl-2、p53 expression and Epstein-Barr virus infection in primary nasopharyngeal carcinoma[J];Journal of Clinical Otorhinolaryngology;2001-10
10 WANG Shuangle 1 JIANG Yuanshi 1 HUANG Hecheng 1 YANG Qiang 2 ( 1Department of Otolaryngology-Head and Neck Surgery, Shantou City Central Hospital, Shantou,515031,China; 2Department of Otolaryngology-Head and Neck Surgery,People's Hospital of Wuhan University);Expression and correlation with metastasis of E-cadherin,CD44H,matrix metalloproteinase-3,nm23H_1 and VEGF in nasopharyngeal carcinoma[J];Journal of Clinical Otorhinolaryngology;2004-08
【Secondary References】
Chinese Journal Full-text Database 5 Hits
1 LENG Lei,LIU Teng-fei,HUANG Zhong-xi,XIE Wei-bing,YAO Kai-tai Cancer Institute,Southern Medical University,Guangzhou 510515,China;Establishment of a nude mouse model of nasopharyngeal carcinoma lymph node metastasis and screening of the metastasis-related signature genes[J];Journal of Southern Medical University;2008-09
2 YANG Chunli,SHEN Airong.Department of Obstetrics and Gynecology,the Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Expression of MIF and VEGF protein and the significance in endometriosis[J];Journal of Practical Diagnosis and Therapy;2008-02
3 ZHANG Shaohui1,GAO Dongsheng2 (1.Tianjin Medical University,Tianjin 300070;2.Department of Cardiology,Affiliated Hospital of Jining Medical College,Jining Shandong 272029,China);Advances of signal transduction of macrophage migration inhibitory factor[J];International Journal of Pathology and Clinical Medicine;2009-01
4 WU Yu-qi, MA Shao-lian, CHEN Guo-zhang, et al.;The Influence of Face Mask Making on Radiation Fields Junction in Nasopharyngeal Carcinoma[J];Journal of Oncology;2008-10
5 CHENG Rong-Jie,LIU Jing-Hua,LENG Wei-Chun.Department of Obstetrics and Gynecology,the First Affiliated Hospital of Jilin University,Changchun 130021,Jilin,China;Expression of macrophage migration inhibitory factor and non-metastasis 23 in ovarian endometriosis[J];Maternal and Child Health Care of China;2009-30
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved