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《Journal of Sun Yat-sen University (Medical Sciences)》 2005-01
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Association of Macrophage Migration Inhibitory Factor with Tumor Neovascularization and Lymph Node Metastasis of Nasopharyngeal Carcinoma

LI Zhi 1, LIN Su-xia 2, LIANG Hui-zhen 1, LIANG Ying-jie 1, HE Jie-hua 2(1. Department of Pathology, Zhongshan Medical College, SUN Yat-sen University, Guangzhou 510080, China; 2. Department of Pathology, Cancer Center, SUN Yat-sen University, Guangzhou 510060, China)  
To detect the expression of macrophage migration inhibitory factor (MIF) and vascular endothelial growth factor (VEGF) in nasopharyngeal carcinoma (NPC), and correlate their expression level with intratumoral microvessel density (IMD) to investigate the mechanism of invasion and metastasis of NPC cells. Forty-five NPC biopsies were collected from the patients with NPC during 1999-2003. Immunohistochemical staining was used for detecting the expression of MIF, VEGF in NPC tissues. The number of IMD was evaluated by counting the CD34-positive neovessels in the most active areas of tumor neovascularization or hotspots. The associations of these indexes with pathological and clinical features were statistically analyzed. The positive expression rates of MIF and VEGF were 78% (35/45) and 71% (32/45), respectively. The expression of MIF showed a correlation with lymph node metastasis. The higher expression of MIF were always found in NPC neoplastic cells with cervical lymph node metastasis than that in NPC without lymph node metastasis (P =0.029). The number of IMD in tumor with metastasis was also significantly higher than that without lymph node metastasis (P =0.026). Meanwhile, the number of IMD counted in MIF positive group (35.1±13.3/HPF) was significantly higher than that in MIF negative group (20.9/HPF±10.2/HPF), P value was 0.003. In addition, the expression of MIF in NPC neoplastic cells with Schmincke growth pattern (67.4%±35.2%) was higher than that in NPC with Regaud growth pattern (32.9%±29.7%), there existed a significantly difference in MIF expression of NPC between two growth patterns (P =0.007). There were positive correlations found for the expression of MIF with VEGF and IMD counting, respectively (P 0.05). However, there was no relationship found in the expression of VEGF with the other clinicalopathological features of NPCs including age, gender, histopathological type, and clinical stage. [Conclusion]MIF cytokine might play an important promoting role in contributing the metastasis of NPC as well as associated with tumor neovascularization and up-regulating the VEGF expression of NPC.
【Fund】: 国家自然科学基金资助项目(30200254);; 广东省自然科学基金资助项目(031672)
【CateGory Index】: R739.63
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