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《Journal of Sun Yat-sen University (Medical Sciences)》 2005-01
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Immune Effect of Recombinant HBV Vaccine for Newborn from Guangdong

CHONG Yu-tian 1, LUO Rui-hong 1, GU Jin 2, ZHAO Zhi-xin 1, LI Jian-guo 1, YAO Ji-lu 1(1. Department of Infectious Disease, 2. Department of Gynaecology and Obstetrics, The Third Affiliated Hospital of SUN Yat-sen University, Guangzhou 510630,China)  
To observe the persistent protective effect of HBV vaccine of recombination yeast for newborn from Guangdong. A prospective study was performed to observe the immune response and side effects of HBV vaccine of recombination yeast for 166 newborn from Guangdong after a cohort follow-up. The objects were divided into mother HBsAg(+) group and mother HBsAg(-) group. The Anti-HBs positive rates and side effects were compared between two groups. (1) The total response rate was 90.4% (150/166) at the age of one. The response rate had no significant difference between two groups (80.6% vs 92.6%, P 0.05) with the odds ratio (OR) and its 95% confidence interval (95%CI) of 0.33 (0.11, 1.00). (2) The total response rate was 90.4% (150/166) at the age of three, with no significant difference of response rate between HBsAg(+) group and HBsAg(-) group [83.9% vs 94.1%, P 0.05; OR=0.33 (0.10,1.08)]. (3) One hundred and fifty responders at the age of one all kept Anti-HBs(+) till they were three years old. After complementary vaccination, the response rates of the original non-responders were 25% (1/4) and 20% (2/10) in HBsAg(+) group and HBsAg(-) group, respectively. (4) No serious side effect was found. [Conclusion]This HBV vaccine of combination yeast could induce anti-HBs response and was safe.
【Fund】: 广东省卫生厅基金资助项目(A1998203)
【CateGory Index】: R186
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