Full-Text Search：
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Sun Yat-sen University (Medical Sciences)》 2005-01
Add to Favorite Get Latest Update

Immune Effect of Recombinant HBV Vaccine for Newborn from Guangdong

CHONG Yu-tian 1, LUO Rui-hong 1, GU Jin 2, ZHAO Zhi-xin 1, LI Jian-guo 1, YAO Ji-lu 1(1. Department of Infectious Disease, 2. Department of Gynaecology and Obstetrics, The Third Affiliated Hospital of SUN Yat-sen University, Guangzhou 510630,China)  
To observe the persistent protective effect of HBV vaccine of recombination yeast for newborn from Guangdong. A prospective study was performed to observe the immune response and side effects of HBV vaccine of recombination yeast for 166 newborn from Guangdong after a cohort follow-up. The objects were divided into mother HBsAg(+) group and mother HBsAg(-) group. The Anti-HBs positive rates and side effects were compared between two groups. (1) The total response rate was 90.4% (150/166) at the age of one. The response rate had no significant difference between two groups (80.6% vs 92.6%, P 0.05) with the odds ratio (OR) and its 95% confidence interval (95%CI) of 0.33 (0.11, 1.00). (2) The total response rate was 90.4% (150/166) at the age of three, with no significant difference of response rate between HBsAg(+) group and HBsAg(-) group [83.9% vs 94.1%, P 0.05; OR=0.33 (0.10,1.08)]. (3) One hundred and fifty responders at the age of one all kept Anti-HBs(+) till they were three years old. After complementary vaccination, the response rates of the original non-responders were 25% (1/4) and 20% (2/10) in HBsAg(+) group and HBsAg(-) group, respectively. (4) No serious side effect was found. [Conclusion]This HBV vaccine of combination yeast could induce anti-HBs response and was safe.
【Fund】： 广东省卫生厅基金资助项目(A1998203)
【CateGory Index】： R186
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 2 Hits
1 ZHANG Xue-yan;WANG Yue-qi;ZHOU Yong-kang;Department of basic medicine, Medical and Nursing School, Chengdu University;;Safety of hepatitis B vaccine of children in China: a meta-analysis[J];现代预防医学;2015-09
2 CHEN Qian1,2,ZHU Jian-qiong3,HUANG Zhen-yu3,LU Jia-hai2(1.Shijie Hospital of Dongguan,Dongguan 523290; 2.The School of Public Health,Sun Yat-sen University,Guangzhou 510080; 3.Center for Diease Control and Prevention of Dongguan City,Dongguan 523290,China);Evaluation on the Efficacy of the Recombination Yeast Hepatitis B Vaccine Immunization Program of Infants[J];热带医学杂志;2007-08
【Citations】
Chinese Journal Full-text Database 4 Hits
1 LU Qing, ZHU Qirong, XIONG Sidong, et al * Children′s Hospital, Shanghai Medical University, Shanghai 200032;Hepatitis B virus S gene mutants in infants who were infected despite immunoprophylaxis[J];中华儿科杂志;1999-12
2 ZHU Qirong, YU Guangjun, LU Qing, et al. Childrens Hospital, Shanghai Medical University, Shanghai 200032;A study on the relationship between cytokines and failure of immunization with hepatitis B vaccine in children who had intrauterine HBV infection[J];中华儿科杂志;1999-07
3 LINXimin* , XUZhiyi,OU- YANGPeiying, et al. * Department of Epidemiology,School of Public Health,Shanghai Medical University,Shanghai200032;Long- term efficacy study of hepatitis Bvaccination in newborns- results of 11 years’follow - up[J];中华流行病学杂志;1999-03
4 Zhang Yaohua; Yao Huiling; Shen Li2(Beijing Hospital Jishuitan. Beijing 100035) (Beijing Municipal Centre for Hygiene and Epidmic Contol 100013);Observation of Immunity-Persistence of Natively-manufactured Hepatitis B Plasma-derived Vaccine[J];中华实验和临床病毒学杂志;1995-04
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Pei Bin;MIAO Xiao-hui;Department of Infection Disease,Shanghai International Medical Center;;Antiretroviral therapy progress and controversy of HBV-infected pregnancy[J];中国实用内科杂志;2014-06
2 LI Cui-fang,LIU You-ping,HUANG Gui-biao,et al.( Wuzhou City Center for Disease Control and Prevention,Wuzhou 543002,Guangxi Zhuang Autonomous Regin,China);Assessment of the Immune Serological Efficacy of Newborns after Primary Vaccination and Reimmunization to the Non-and-low Immune Response Newborns of Hepatitis B Vaccine Made by Recombinant Deoxyribonucleic Acid Techniques in Saccharomyces Cerevisiae Yeast[J];中国疫苗和免疫;2013-03
3 MEI Yan,LIAO Tao,DENG Xin-Qiong,TANG Ling,CAI Ren.Liuzhou Matemal and Child Health Hospital in Guangxi,Liuzhou 545001,China;Research on relevance between newborn immune failure with intrauterine infection HBV and IL-2,IFN-γ expression[J];中国免疫学杂志;2012-12
4 QIAN Fu-chu, ZOU Wei-hua,QIN Ji-qu,DAI Li-cheng. Huzhou Central Hospital,Huzhou 313000,Zhejiang,China;Variations of hepatitis B virus S gene “a"determinant among children with failure of immunization in Huzhou city[J];中华实验和临床病毒学杂志;2012-03
5 LI Jian,REN Hong,LU Lu,et al.(Shanghai Municipal Center for Disease Control and Prevention,Shanghai 200336,China);Study of Persistence Effect of Hepatitis B Vaccine Made by Recombinant Deoxyribonucleic Acid Techniques in Saccharomyces Cerevisiae Yeast on Neonates in Shanghai[J];中国疫苗和免疫;2011-05
6 WU Wei-shou,SUN Chao-mei,JIANG Ming-bo,ZHANG Guo-hua,HU Kai,MU Wen,SU Fei,ZHOU Zi-rong(Huangpu District Center for Disease Control and Prevention,Shanghai,200011,China);A Follow-up on Efficacy of Immunization of Yeast-derived Recombinant Hepatitis B Vaccine after 11 Years[J];职业与健康;2011-17
7 XIAO Shi-hai*,LIU Lian-geng *Yancheng Inspection Quarantine Bureau,Yancheng,Jiangsu 224002,Chian;Research progress of non(low)-response cause to HB vaccine and corresponding countermeasures[J];中国国境卫生检疫杂志;2011-01
8 WANG Feng,LIU Yan-cheng,WANG Kai-li,et al.(State Key Laboratory for Infectious Disease Control and Prevention,National Institute for Viral Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 100052,China);Analysis on HBV Epidemical Trend of People Age<20 from Rural Areas of Zhaodong[J];中国疫苗和免疫;2010-03
9 XIE Xi-lun,WANG Jun(Yanzhou Municipal Center for Disease Control and Prevention,Yanzhou 272100,Shandong,P.R.China);Factors associated with failure in immunization with hepatitis B vaccine[J];中国热带医学;2009-06
10 GONG Li -ping, ZHOU Wei, LI Yong. (Hainan Frontier Defence Garrison Hospital, Haikou 570203, Hainan, P. R.China );Observation on the effect of interruption of vertical transmnission of hepatitis B virus from mother to their fetus and babies by vaccination[J];中国热带医学;2009-01
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 YE Bao-qiang(Shanghui Hospital of Dantu District,Jiangsu Zhenjiang 212124,China);CLINICAL OBSERVATION OF INFANTS VACCINATED WITH HEPATITIS B VACCINE TO PRETENT HEPATITIS B[J];承德医学院学报;2012-04
2 WANG Qing-tu, ZHANG Cheng-yuan, LI Zhong-liang , ZHANG Hai-kun, DONG Tian-liang. Weifang Maternal and Child Health Care Hospital, 261011 Weifang, Shandong Province, China.;Impact of Immune Effect to Different Dosage Hepatitis B Virus Vaccine in Premature Infants[J];中华妇幼临床医学杂志(电子版);2012-03
3 DENG Su,ZHANG Jian-guo(Yueyang Municipal Center for Disease Control and Prevention,Yueyang 414000,Hunan,China);Case-controlled Study on Two Versus Three Doses of HBV Vaccine[J];实用预防医学;2011-03
4 Du Liping,Mei Dan (Department of Pharmacy,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100730,China);Safety and adverse events of immunization[J];药物不良反应杂志;2010-04
5 LI Hai-xia,WU Bing-yi,FENG Zhi-chun.(1.Bayi Children' Hospital Affiliated to Bejing Military Garrison General Hospital, Bejing 100700,P.R.China);Clinical characteristics of vaccination associated thrombocytopenic purpura[J];中国热带医学;2010-07
6 WANG Ya-long~*,CHEN Wen-yu,XU Wen-guo,WANG Xu, LIU Yan,WU Jian-fang,CHEN Jiang-ting.* Changzhou Center for Disease Control and Prevention, Changzhou 213003,China;Safety and immunogenicity of combined hepatitis A and hepatitis B vaccine according to 0 and 6 months schedule in healthy children[J];中华预防医学杂志;2010-02
7 WANG Wen-jun1,ZHANG Jing1,LIU Hu1,JIANG Bao-fa2,HAN Yang-li3(1.The Preventive Department of Jining Medical College,Jining 272013;2.School of Public Health,Shandong University,Jinan 250012;3.No.3 Hospital of Yankuang Group,Jining 272072,China);Evaluation of Immunogenicity of Recombinant Yeast-Derived Hepatitis B Vaccine in Population of A Coal-mine Area[J];热带医学杂志;2007-10
8 CHEN Yin-zhong,JIANG Ren-jie,SHEN Jin-jin,et al.(Yancheng Recombinant Center for Disease Control and Prevention.Yancheng 224002,Jiangsu,China);Study on Booster Vaccination With Domestics Combined Hepatitis A and B Vaccine Among Children[J];中国计划免疫;2007-01
9 GONG Xiao-hong,WANG Fu-zhen,LI Hui,et al.(Center for Disease Control and Preventim of Daxing District of Beijing,Beijing 102600,China);The Follow-up Study on Immunization Effect of Hepatitis B Gene Recombined Vaccine for the New Infants During Six Years[J];中国计划免疫;2006-04
10 LEI Ren-yu,LUO Yao-xing,XIE Xin,et al.(Guangdong Provincial Center for Disease Control and Prevention,Guangzhou 510300,Guangdong,China);Serological Epidemiology of HBsAg and Anti-HBs for Children in Zhujiang Delta Area of Guangdong Province[J];中国计划免疫;2006-02
【Secondary References】
Chinese Journal Full-text Database 3 Hits
1 Jia Tao;Wang Rui;China National Biotec Group Company Limited;;Research status and strategies of preventing mother-to-child transmission of hepatitis B[J];中华预防医学杂志;2016-02
2 ZHOU Xianya,LIU Yanyin,SU Haiyan,et al(Department of Epidemic Prevention,Red Cross Hospital of Guangzhou Economic-Technological Development District,Guangzhou510530,China);The Immune Efficacy among 416 Newborns after HepB in Guangzhou[J];临床医学工程;2008-11
3 ZHOU Dong-sheng, TANG Hui-zhu, YANG Gang, JIANG Jiu-xi(Department of Infectious Diseases, the First Affiliated Hospital of Guilin Medical College,Guilin 541001, China);Analysis of the Related Factor of Chronic HBV Infection in High-Risk Infants[J];热带医学杂志;2008-04
【Secondary Citations】
Chinese Journal Full-text Database 3 Hits
1 Zhu Qirong, Lǜ Qing, Yu Hui, et al. Children`s Hospital, Shanghai Medical University, Shanghai 200032;A preliminary study on the mechanism and prognosis of immune failure of vaccination against HBV in intrauterine HBV infected infants[J];中华儿科杂志;1997-07
2 Xu Zhiyi Liu Chongbai Yan Tianjiang Sha QinghongSun Yongde Fu Tingyang Xi Longfu Department of Epidemiology, Shanghai Medical University Sanitation and Anti-epidemic Station of Nanshi district, Shanghai Sanitation and Anti-epidemic Station of Province Hunan Sanitation and Anti-epidemic Station of Province Guangdong Sanitation and Anti-epidemic Station of Province Hebei Institute of Virology, Chinese Acadamy of Preventive Medicine, Beijing;EVALUATION OF EFFECTIVENESS OF LARGE-SCALE HEPATITIS B VACCINATION IN NEONATES[J];病毒学报;1991-S1
3 Liu Chongbai Xu Zhiyi Cao Huilin Sun Yongde Cheng Dabao Jing Qing Chang Meizheng Xie Yongfu Institute of Virology, Chinese Academy of Preventive Medicine, Beijing Department of Epidemiology, Shanghai Medical University Sanitation and Anti-epidemic Station of Province Hebei Sanitation and Anti-epidemic Station of Province Hunan Sanitation and Anti-epidemic Station of City Kaifeng, Henan Sanitation and Anti-epidemic Station of Province Heilongjiang;SERO-EPIDEMIOLOGY OF HBV INFECTION IN FOUR PROVINCES IN CHINA[J];病毒学报;1991-S1
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved