Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Sun Yat-sen University (Medical Sciences)》 2005-01
Add to Favorite Get Latest Update

Effects of Ulinastatin on Inflammatory Factors in Patients after Chemotherapy during One Lung Ventilation

MA Wu-hua 1, WU Yi-long 2, LI Zhao-xia 3, HEI Zhi-qing 1, CHEN Xin-zhi 1(1. Department of Anesthesiology, The Third Affiliated Hospital, SUN Yat-sen University, Guangzhou 510630, China; 2. Tumour Center of Guangdong Provincial People's Hospital, Guangdong 510080,China; 3. Department of Clinical Laboratory, The Third Affiliated Hospital, SUN Yat-sen University, Guangzhou 510630, China)  
To investigate the effects of ulinastatin on inflammatory factors in patients after chemotherapy during one lung ventilation.Thirty patients with lung cancer after chemotherapy for selective pulmonary surgery(ASA Ⅱ-Ⅲ) were selected and were randomly divided into two groups: control group (group C, n = 15) and ulinastatin group (group U, n=15). Group U: Patients received ulinastatin 10 000 U·kg-1 iv after induction of anesthesia. Group C: Patients received equal volume of normal saline instead of ulinastatin. Blood concentrations of IL-8 and IL-10 from peripheral vein were determined after induction of anesthesia (S1), 40 min after one-lung ventilation in the lateral position (S2), 90 min after one-lung ventilation in the lateral position (S3), 30 min after two-lung ventilation at the end of the operation (S4); 24 h after operation (S5). Plasma IL-8 concentrations increased significantly at S 3-5 in both group as compared with the baseline values and were significantly lower at S 3-4 in ulinastatin group than in group C (P 0.05). Plasma IL-10 mass concentrations increased significantly at S 3-5 in both groups and were significantly hegher at S3-4 in ulinastatin group than in group C (P 0.05). [Conclusion] Ulinastatin can effectively decrease the level of plasma IL-8 and upgrade the level of plasma IL-10 in the patients after chemotherapy.
【CateGory Index】: R614.2
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 1 Hits
1 MA Wu-hua1,WU Yi-long2,LING Qiu-xiong3(1Department of Anesthesiology,The First Affiliated Hospital,Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,China;2Tumor Center,3 Department of Research Center of Medical Science,People's Hospital of Guangdong Province,Guangzhou 510080,China);Effects of ulinastatin on IL-6,IL-8 and TNF-α mRNA expression during one lung ventilation[J];Chinese Journal of Pathophysiology;2007-02
【Citations】
Chinese Journal Full-text Database 2 Hits
1 MAWu-hua, GAO Wan-ling, GUAN Jian-qiang, LUO Gang-jian, LI Shang-rong (Department of Anesthesiology, The Third Affiliated Hospital, SUN Yat-sen University, Guangzhou 510630, China);Effects of Different Tidal Volume During One Lung Ventilation on Systemic Oxygenation and Intrapulmonary Shunt[J];Journal of Sun Yat-sen University (Medical Sciences);2003-01
2 MA Wu-hua , GUAN Jian-qiang , GAO Wan-ling, WU Yi-long, LI Shang-rong, ZHOU Shao-li (Department of Anesthesiology, The Third Affiliated Hospital, SUN Yat-sen University, Guangzhou 510630, China; Tumour Center of Guangdong Province People's Hospital, Guangzhou 510100, China);Effects of Non-ventilated Lung with CPAP on Systemic Oxygenation and Intrapulmonary Shunt During One lung Ventilation[J];Journal of Sun Yat-sen University (Medical Sciences);2004-01
【Co-citations】
Chinese Journal Full-text Database 5 Hits
1 LIN Wen-Qian1,2,LU Xiao-Yun1,2,CAO Long-Hui1,2,WEN Li-Li1,2,BAI Xiao-Hui1,2,ZHONG Zhong-Jian1,2 1.State Key Laboratory of Oncology of South China,Guangzhou,Guangdong,510060,P.R.China 2.Department of Anesthesiology,Cancer Center,Sun Yat-sen University,Guangzhou,Guangdong,510060,P.R.China;Effects of the Lung Protective Ventilatory Strategy on Proinflammatory Cytokine Release During One-lung Ventilation[J];Chinese Journal of Cancer;2008-08
2 MA Wuhua WU Yi-long LI Zhao-xia,Department of Anesthesiology,First Hospital,Traditional Chinese Medicine University of Guangzhou,Guangzhou 510405,China;Protective effects of ulinastatin on lung in patient undergoing lung resection after chemotherapy[J];Chinese Journal of Anesthesiology;2006-01
3 MA Wu hua 1, WU Yi long 2, LI Zhao xia 3 1.Department of Anesthesiology, The Third Affiliated Hospital, SUN Yat sen University, Guangzhou 510630,China;2.Lung Cancer Institute,Guangdong Prorincial People's Hospital;3.Department of clinical Laboratory,3rd Hospital Affiliated of Sun yat sen University;The Effects of Ulinastatin on Oxygen Free Radical and IL-6、IL-8、TNF-a During One Lung Ventilation after Chemotherapy to Patients with Lung Cancer[J];Cancer Research On Prevention and Treatment;2004-08
4 MA Wu-hua , GUAN Jian-qiang , GAO Wan-ling, WU Yi-long, LI Shang-rong, ZHOU Shao-li (Department of Anesthesiology, The Third Affiliated Hospital, SUN Yat-sen University, Guangzhou 510630, China; Tumour Center of Guangdong Province People's Hospital, Guangzhou 510100, China);Effects of Non-ventilated Lung with CPAP on Systemic Oxygenation and Intrapulmonary Shunt During One lung Ventilation[J];Journal of Sun Yat-sen University (Medical Sciences);2004-01
5 Cui Wei Department of Anesthesiology,The Affiliated Hospital of Chifeng University,Chifeng 024001,China;Influence of one-lung ventilation on respirotorg management for patieats undergoing video-assisted thoracoscopic surgery and related anesthesia strategies[J];Journal of Cardiovascular and Pulmonary Diseases;2012-02
【Co-references】
Chinese Journal Full-text Database 5 Hits
1 GUO Yu-biao 1, LI Zhi-ping 1, XIE Can-mao 1, CHEN Yong-xiong 2, YIN Pei-da 2 (? 1?Respiratory Division,1st Affiliated Hospital,? 2?Renal Research Institute, Sun Yat-sen University of Medical Sciences, Guangzhou 510080, China);Role of macrophage and intercellular adhesion molecule-1 in the pathogenesis of oleic-acid-induced rat acute lung injury[J];Chinese Journal of Pathophysiology;2001-09
2 ;鱼腥草对油酸性急性肺损伤大鼠肺组织TNF-α表达的影响[J];Chinese Journal of Pathophysiology;2003-04
3 MA Wu-hua~1, GAO Wan-ling~1, WU Yi-long~2, LUO Gang-jian~1, LI Shang-rong~1, GUAN Jian-qiang~1(~1Department of Anesthesiology,?~2?Cardiothoracic surgery, The Third Affiliated Hospital, SUN Yat-sen University, Guangzhou 510630, China) [;Effects of non-ventilated lung with nitrous oxide on intrapulmonary oxygenation and lactic acid level in arterial blood during one lung anesthesia[J];Chinese Journal of Pathophysiology;2004-11
4 CHEN Xuejun, WEN Liang, YIN Changlin, et al Department of Aneshesiology, 254th Hospital of PLA, Tianjin 300142;Role of intercellular adhesion molecule-1 in the lung inury induced by mechanical ventilation[J];Chinese Journal of Anesthesiology;2000-09
5 DING Xue-gin, LIU Gui- ming , WANG Junrke , et al. Department of Anesthesiology , First Affiliated Hospital, China Medical University, Shenyang 110001 , China;Effects of carbon monoxide inhalation on acute hypoxic pulmonary arterial hypertension and acute hypoxic lung injury J[J];Chinese Journal of Anesthesiology;2003-05
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 CHEN Yong-lun(Qujing Municipal First People's Hospital,Qujing 655000,Yunnan,P.R.China);Impact of one lung ventilation on the levels of TNF-α,IL-6,IL-8 and SOD in 46 lung cancer patients[J];China Tropical Medicine;2010-05
【Secondary Citations】
Chinese Journal Full-text Database 4 Hits
1 GUAN Zhongzhen, CHEN Ruqin, XU Guangchuan, et al. Medical Oncology Department of Cancer Center, Sun Yatsen University of Medical Sciences, Guangzhou 510060,China;Gemcitabine in the treatment of advanced nonsmallcell lung cancer[J];CHINESE JOURNAL OF CANCER;1999-03
2 SHAO Guiqian, LI Zhixue,LI Jixue, et al Department of Anesthesiology,First Affiliated Hospital,Harbin Medical University,Harbin 150001;Effects of non-ventilated lung insufflated with nitrous oxide on intrapulmonary shunt during one lung anesthesia[J];CHINESE JOURNAL OF ANESTHESIOLOGY;1999-01
3 MAWu-hua, GAO Wan-ling, GUAN Jian-qiang, LUO Gang-jian, LI Shang-rong (Department of Anesthesiology, The Third Affiliated Hospital, SUN Yat-sen University, Guangzhou 510630, China);Effects of Different Tidal Volume During One Lung Ventilation on Systemic Oxygenation and Intrapulmonary Shunt[J];Journal of Sun Yat-sen University (Medical Sciences);2003-01
4 ZHA Aiqin, GUO Genfa (Zhejiang Cancer Hospital, Hangzhou 310022 , P.R. China);Advanced Nonsmall cell lung cancer treatment with Vinorelbine, Docetaxel, Gemcitabine combined with Cisplatine, respectly: a report of 95 patients[J];Tumor;2002-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved