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《Journal of Sun Yat-sen University (Medical Sciences)》 2005-01
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Comprehensive Treatment and Clinicopathology, Immunohistochemistry and DNA Contents of Carcinosarcoma of Parotid Gland

WU Jun-wei 1, CHEN Wei-liang 2, YANG Zhao-hui 2, LI Hai-gang 3, ZENG Yun-jie 3, Huang Zhi-quan 2(1. Department of Stomatology, The First People′s Hospital of Foshan, Foshan 528000; 2. Department of Oral and Maxillofacial Surgery, 3. Department of Pathology, The Second Affiliated Hospital, SUN Yat-sen University, Guangzhou 510120, China)  
To investigate the pathological characteristics, biological behavior and effective treatment of parotid gland carcinosarcoma. Two patients with parotid gland carcinosarcoma were treaded with total parotidectomy and radiotherapy of 65 Gy to 70 G in total dose, and the surgical specimens were detected by clinicopathology, immunohistochemistry, and flow cytometry (FCM). Histopathological examination showed that the tumor contained both malignant epithelial components(carcinoma) and malignant mesenchymal components (sarcoma). Immunohistochemistry showed that the epithelial cells were stained strongly for cytokeratin and mesenchymal cells for vimentin, and FCM analysis showed that the tumor cell DNA was aneuploid and high of synthesis phase fraction. [Conclusion] Carcinosarcoma of parotid gland is an extremely malignant tumor. Immuno-histochemistry is valuable for the diagnosis. It is possible to achieve a longer survival with comprehensive treatment.
【Fund】: 广东省重大科技基金资助项目(2KM04404S)
【CateGory Index】: R739.87
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Chinese Journal Full-text Database 2 Hits
1 Zhou Jun, Dong Shaozhong, Jin Yan, Yang Lianjia (Department of Oral Pathology, Stomatological Hospital, the Fourth Military Medical University, Xian 710032);Clinicopathological analysis of salivary carcinosarcoma[J];临床与实验病理学杂志;2002-01
2 CHEN Wei liang, LI Hai gaung, KONG Qin yu, CHEN Gaung ye Depatment of Oral and Maxillo facial Surgery, Sun Yat Sen Memorial Hospital, Sun Yat Sen University of Medical Sciences, Guangzhou 510120;EVALUATION OF DNA CONTENTS AND AgNOR IN STUDY OF CELLULAR PROLIFERATIVE ACTIVITY OF PAROTIC GLAND MIXED TUMOR[J];口腔颌面外科杂志;2000-01
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