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《Journal of Sun Yat-Sen University(Medical Sciences)》 2008-01
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Iressa in Combination with Cisplatin on Inhibiting Tongue Squamous Cell Carcinoma

SUN Chuan-zheng1,2, CHEN Fu-jin2, ZENG Mu-sheng2, LI Xiao-jiang1,SONG Li-bing2, LI Man-zhi2, ZENG Zong-yuan2, SUI Jun1( 1. Department of Head and Neck Surgery, The Third Affiliated Hospital, Kunming Medical College, Kunming 650118, China; 2. State Key Laboratory of Oncology in Southern China∥Departmemt of Head and Neck Surgery, Cancer Center, SUN Yat-sen University, Guangzhou 510060, China )  
[Objectives] To evaluate the inhibiting effects of Iressa in combination with cisplatin (DDP) on tongue squamous cell carcinoma lines Tscca and Tca8113. [Methods] The effect of Iressa in combination with cisplatin on tongue squamous cell carcinoma lines (Tscca and Tca8113) was detected by MTT assay. [Results] The IC50s of Iressa on Tscca and Tca8113 cell lines were 18.03 μmol/L and 29.98 μmol/L, respectively (P = 0.002). Synergistic inhibiting effects were found when Iressa in combination with cisplatin, especially Iressa used before the cisplatin 24 h or 48 h. [Conclusions] Iressa can inhibit the proliferation of tongue squmous cell carcinoma lines by the manner of dose-dependent and sequence-dependent. Synergistic inhibiting effects were found when Iressa in combination with cisplatin.
【Fund】: 广东省科技计划项目(2KM04505S)
【CateGory Index】: R739.8
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