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《Journal of Sun Yat-Sen University(Medical Sciences)》 2008-01
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Effect of Loading Infusion with Hydroxyethyl Starch 200/0.5 or 130/0.4 Solution on Platelet Activity in Patients with Coronary Heart Disease During Perioperative Period

LIANG Hua, HUANG Qiong, WEN Xian-jie, ZHANG Ya-jun,LI Heng, LIU Hong-zhen, YANG Cheng-xiang( Department of Anesthesiology, The Affiliated Foshan Hospital, SUN Yat-sen University, Foshan 528000, China )  
[Objective] To investigate the effect of loading infusion with hydroxyethyl starch 200/0.5 or 130/0.4 solution on platelet activity in the patients with coronary heart disease (CHD) during perioperative period. [Methods] Forty-five patients with coronary heart disease who received cholecystectomy were randomly and equally assigned into 3 groups: hydroxyethyl starch HES200/0.5 solution group (groupⅠ), HES130/0.4 solution group (groupⅡ) and lactated Ringers' (RL) solution group (group Ⅲ, as control group). HES200/0.5 solution, HES130/0.4 solution, or RL solution were respectively infused at a dose of 10 mL.kg-1 over a period of 30 min before surgery. Flow cytometry was used to measure the expression of GPIIb/IIIa and GMP-140 before infusion (T0), at the end of infusion (T1), at 1 h after infusion (T2) and at 2 h after surgery end (T3). [Results] The expression of GPⅡb/Ⅲa and GMP-140 in groupⅠ was decreased significantly after infusion as compared to the baseline values at T0(P 0.05). The expression of GPⅡb/Ⅲa in group Ⅱ was decreased significantly after infusion as compared to that at T0 (P 0.05); Compared with group Ⅱand group Ⅲ, the expression of GPⅡb/Ⅲa and GMP-140 after infusion was significantly lower (P 0.05) in group Ⅰ. Compared with group Ⅲ, the expression of GPⅡb/Ⅲa and GMP-140 after infusion was significantly lower in group Ⅱ (P 0.05). The expression of GMP-140 was increased significantly at T2 and T3 than that at T0 in group Ⅲ (P 0.05). [Conclusion] Infusion with HES solution can inhibit excessive activation of platelet in the patients with coronary heart disease during perioperative period and HES200/0.5 had the stronger effect than that of HES130/0.4, which may prevent aggravation of the disease and ameliorate prognosis.
【CateGory Index】: R614
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