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Clinical Significance of Level of Macrophage Inflammation Protein in Serum for the Diagnosis of Multiple Myeloma Bone Disease

SU Chang,XU Duo-rong,ZOU Wai-yi,XU Hui-ru,HUANG Shan,LI Juan,LUO Shao-kai(Department of Hematology,First Affiliated Hospital,Sun Yat-sen University,Guangzhou 510080,China)  
【Objective】To investigate the relationship between the level of macrophage inflammation protein(MIP) in serum of the patients with multiple myeloma(MM) and multiple myeloma bone disease(MBD).【Method】 The serum levels of MIP-1α and MIP-1β,soluble ligand of receptor activator of nuclear factor kappaB(sRANKL) and osteoprotegerin(OPG) which are in the downstream signaling factors of MIP-1α and MIP-1β,tartrate-resistant acid phosphatase-5b(TRAP-5b) and C-terminal telopeptide of collagen Ⅰ(CTP-Ⅰ) which are indexes for metabolism of osteoclast(OC) were detected in MM patients with first diagnosed(n = 42,experimental group) and healthy persons(n = 25,control group) by enzyme-linked immunosorbent assay.X-ray was also used to determine bone damage in these patients with MM at the same time.According to these results acquired,we analyzed the correlation between the levels of MIP-1α and MIP-1β and the ratio of sRANKL/OPG,levels of TRAP-5b and CTP-Ⅰ and MBD.【Result】 The levels of MIP-1α(median value was 125.18 ng/mL) and MIP-1β(median value was 134.35 ng/mL) were higher than that of in the control group,respectively(P 0.05).All patients in experimental group were divided into group with MBD(n = 29) and group without MBD(n = 13).We found the levels of MIP-1α and MIP-1β in group with MBD were higher than that in group without MBD(P 0.05).meanwhile,we also found the levels of MIP-1α and MIP-1β was closely related to the ratio of sRANKL /OPG(γ values were 0.641 and 0.451,respectively,P 0.05),the level of TRAP-5b(γ values were 0.547 and 0.529,respectively,P 0.05) and CTP-Ⅰ(γ values were 0.476 and 0.512,respectively,P 0.05).【Conclusion】 The levels of MIP-1α and MIP-1β in MM patients are not only significantly elevated but also closely related to the degree of MBD and they could increase the metabolism of OCs and result in MBD by mediating the ratio of sRANKL/OPG.Therefore,The levels of MIP-1α and MIP-1β might be used as a better reference index for the diagnosis of MBD.
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