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Expression of Peripheral Blood Th17 Cells in Patients with Chronic Rejection after Kidney Transplantation

ZHANG Sheng-ping1,NA Ning1,FU Qian2,HONG Liang-qing1,HUANG Zheng-yu1, MIU Bin1,ZHAO Da-qiang1,LI Heng1(1.Department of Kidney Transplantation,Third Affiliated Hospital,Sun Yat-sen University,Guangzhou 510630,China; 2.Department of Organ Transplantation,First Affiliated Hospital,Sun Yat-sen University,Guangzhou 510080,China)  
【Objective】 To investigate the association between the expression of peripheral blood Th17 cells,relevant cytokines in blood and the chronic rejection after kidney transplantation.【Methods】 From January 2007 to August 2010,a total of 75 samples were collected in First and Third Affiliated Hospital,Sun Yat-sen University,including patients with uremia(PU group),non-chronic rejection in six month after kidney transplant(NCR group),and chronic rejection in six month after kidney transplant(CR group) and 25 patients for each group.The expression of peripheral blood Th17 cells were measured by FCM and interleukin-17(IL-17),interleukin-22(IL-22),and interleukin-23(IL-23) levels were evaluated by ELISA.Then we analyzed the differences between three groups.【Results】 The expression of Th17 cells in chronic rejection group was(3.8 ± 1.7)%,which was significantly lower than those in uremia group(22.0 ± 11.0)% and non-chronic rejection group(17.2 ± 8.0)%(P values 0.01).The IL-17 levels in chronic rejection group were(7.8 ± 1.3)pg/mL,which were also significantly lower than those in uremia group(20.4 ± 9.0)pg/mL(P 0.01) and non-chronic rejection group(17 ± 6.0)pg/mL(P 0.05).However,there were no statistically significances in three groups with respect to the levels of IL-22 and IL-23(P values 0.05).【Conclusion】 In peripheral blood,Th17 cells might play important role in the activation of the chronic rejection after kidney transplantation through increased secretion of IL-17.
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