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《Journal of Sun Yat-sen University(Medical Sciences)》 2014-01
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Abnormal Expression of GDF9 and BMP15 in Unstimulated Ovarian Tissue in Patients with PCOS

WEI Li-na;LI Li-lin;FANG Cong;HUANG Rui;LIANG Xiao-yan;Reproductive Medicine Research Center,The Sixth Affiliated Hospital,Sun Yat-Sen University;  
. 【Objective】 To determine the expression levels of GDF9 and BMP15 in unstimulated ovarian tissues from PCOS patients and normal ovulatory women, and compare the differences between the two groups. 【Methods】 The unstimulated ovarian tissues were collected from PCOS patients and normal ovulatory women. Immunohistochemical staining was used to detect the expression levels of GDF9 and BMP15 both in oocytes and granulosa cells within the tissues. 【Results】 Both the GDF9 and BMP15 were stage dependently expressed in oocytes and granulosa cells within the ovarian tissues. The expression of GDF9 was lower and delayed in oocytes and granulosa cells of PCOS tissues than in control group(P 0.05), the similar result was obtained for BMP15 in granulosa cell of PCOS tissues(P 0.05). However, the expression of BMP15 was comparable in PCOS oocyte and normal control(P 0.05). 【Conclusion】 The expression features of GDF9 and BMP15 demonstrate the stage-dependent characteristic both in oocytes and granulosa cells without ovarian stimulation. The expression of two factors was reduced and delayed in the early follicular phase in PCOS tissues, suggesting that might be associated with aberrant PCOS follicular development.
【Fund】: 国家自然科学基金(81200476);; 教育部博士点基金(20090171110059;20120171120122);; 广东省自然科学基金(S2012040007770;S2011010004621);; 广东省医学科研基金(B2012150)
【CateGory Index】: R711.75
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