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《Journal of Sun Yat-sen University(Medical Sciences)》 2014-01
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Expression of PBR and Its Correlation with Clinicopathologic Characteristic and Prognosis in Human Hepatocellular Carcinomas

PAN Jia-hao;CHEN Dong-tai;XING Wei;HUANG Yang;WEN Li-li;ZHU Cui-zhen;YUAN Yun-fei;ZENG Wei-an;Department of Anesthesiology,State Key Laboratory of Oncology in South China//Cancer Center of Sun Yat-sun University;Department of Hepatobiliary Oncology,State Key Laboratory of Oncology in South China//Cancer Center of Sun Yat-sun University;  
【Objective】 To investigate the expression of peripheral benzodiazepine receptor(PBR) in human hepatocellular carcinoma(HCC) and its correlation with clinicopathologic characteristic and prognosis. 【Methods】 The expression of PBR protein was detected with immunohistochemical EnVision plus non-hiotin technique in 109 cases of human hepatocellular carcinomas. The correlation with characteristic and prognosis were statistically analyzed. 【Results】 The positive expression rate of PBR protein in human hepatocellular carcinomas was 62.4%(68 / 109). The expression of PBR protein was positively related to tumor size, tumor differentiation, tumor capsular, satellite nodule and vascular invasion. The expression of PBR protein was correlation with poor overall survival(OS) and recurrence-free survival(RFS). Furthermore, the expression of PBR protein was identified as an independent prognostic marker for OS and RFS though Cox multivariate analysis. 【Conclusion】 The expression of PBR protein was positive in most human HCC, and it was associated with tumor differentiation, invasion and metastasis. Furthermore, the expression of PBR protein was an independent prognostic marker for HCC.
【Fund】: 国家自然科学基金(81271246);; 教育部博士点基金(20120171110096);; 广东省科技计划项目(2012B031800367)
【CateGory Index】: R735.7
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