Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Sun Yat-sen University(Medical Sciences)》 2014-01
Add to Favorite Get Latest Update

Expression of PBR and Its Correlation with Clinicopathologic Characteristic and Prognosis in Human Hepatocellular Carcinomas

PAN Jia-hao;CHEN Dong-tai;XING Wei;HUANG Yang;WEN Li-li;ZHU Cui-zhen;YUAN Yun-fei;ZENG Wei-an;Department of Anesthesiology,State Key Laboratory of Oncology in South China//Cancer Center of Sun Yat-sun University;Department of Hepatobiliary Oncology,State Key Laboratory of Oncology in South China//Cancer Center of Sun Yat-sun University;  
【Objective】 To investigate the expression of peripheral benzodiazepine receptor(PBR) in human hepatocellular carcinoma(HCC) and its correlation with clinicopathologic characteristic and prognosis. 【Methods】 The expression of PBR protein was detected with immunohistochemical EnVision plus non-hiotin technique in 109 cases of human hepatocellular carcinomas. The correlation with characteristic and prognosis were statistically analyzed. 【Results】 The positive expression rate of PBR protein in human hepatocellular carcinomas was 62.4%(68 / 109). The expression of PBR protein was positively related to tumor size, tumor differentiation, tumor capsular, satellite nodule and vascular invasion. The expression of PBR protein was correlation with poor overall survival(OS) and recurrence-free survival(RFS). Furthermore, the expression of PBR protein was identified as an independent prognostic marker for OS and RFS though Cox multivariate analysis. 【Conclusion】 The expression of PBR protein was positive in most human HCC, and it was associated with tumor differentiation, invasion and metastasis. Furthermore, the expression of PBR protein was an independent prognostic marker for HCC.
【Fund】: 国家自然科学基金(81271246);; 教育部博士点基金(20120171110096);; 广东省科技计划项目(2012B031800367)
【CateGory Index】: R735.7
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 2 Hits
1 TAN Xiao-qiong,ZHOU Yan-bin,LI Yin-huan,HUANG Wan-ling,CAI Xing-dong,ZENG Qing-li(Department of Respiratory Medicine,First Affiliated Hospital of Sun Yat-Sen University,Guangzhou 510080,China);Expression of Hepatoma-derived Growth Factor and Vascular Endothelial Growth Factor in Serum or Tissues of Patients with Lung Cancer[J];Journal of Sun Yat-sen University(Medical Sciences);2011-06
2 CHEN Dong-tai1,ZHONG Wei-qiang1,XING Wei1,HUANG Yang1,WANG Mei-bing1,YUAN Yun-fei2,ZENG Wei-an1(1.Department of Anesthesiology,2.Department of Hepatobiliary Oncology,Key Laboratory of Oncology in South China //Cancer Center of Sun Yat-sun University,Guangzhou 510060,China);Expression of NMDA Receptor 1 Correlates with Clinicopathological Parameters in Human Hepatocellular Carcinomas[J];Journal of Sun Yat-sen University(Medical Sciences);2012-01
Chinese Journal Full-text Database 10 Hits
1 Dou Zhiyong;Yang Min;Peace Hospital of Changzhi Medical College;;Smoking Affects the Effect of Carbamazepine for Primary Trigeminal Neuralgia[J];Journal of Changzhi Medical College;2014-03
2 Zhong Xiaoli;Shang Yangyang;Pan Qiong;Li Shanshan;Liu Yun;Ye Jun;Song Lili;Zhao Jingjing;Peng Zhihong;Wang Rongquan;Institute of Gastroenterology,Southwest Hospital,Third Military Medical University;;Transcriptional regulation of CDX2 gene expression by Ascl2 in colon cancer epithelial cells[J];Journal of Third Military Medical University;2014-18
3 Wei Lanbin;Zhao Lingyun;Pang Rui;Hu Yanwen;Tang Jintian;Department of Biopharmaceuticals,Beijing University of Chinese Medicine;Key Laboratory of Particle&Radiation Imaging,Ministry of Education,Institute of Medical Physics and Engineering Department of Engineering Physics,Tsinghua University;;In vitro investigation on the application of docetaxelin cancer thermochemotherpy[J];Journal of Modern Oncology;2014-04
4 Zhong Yan;Ru Shaoguo;College of Marine Life Science, Ocean University of China;;Research Progress in the Effects of Environmental Pollutants on the Interrenal Stress Axis of Teleosts[J];Asian Journal of Ecotoxicology;2014-03
5 Eun Kyung Choe;Donghee Kim;Hwa Jung Kim;Kyu Joo Park;Department of Surgery, Healthcare Research Institute, Seoul National University Hospital, Healthcare System Gangnam Center, Seoul 135-984, South Korea;Department of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital, Healthcare System Gangnam Center, Seoul 135-984, South Korea;Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, South Korea;Department of Surgery, Seoul National University College of Medicine, Seoul 110-799, South Korea;;Association of visceral obesity and early colorectal neoplasia[J];世界胃肠病学杂志(英文版);2013-45
6 HUANG Yue;CHEN Wen-duo;ZHOU Wei;GAO Yong;DONG Miao;XU Shao-wei;XU Tao;TANG Bin;School of Life Sciences,Zhejiang Sci-Tech University;;Establishment of Replication-deficient Recombinant Adenovirus PCA and Its Influence on Cell Growth of Colon Cancer[J];Journal of Zhejiang Sci-Tech University;2013-06
7 Hang Yuan;Ai-Jun Li;Sen-Lin Ma;Long-Jiu Cui;Bin Wu;Lei Yin;Meng-Chao Wu;Department of the 2~(nd) Special Treatment,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University;;Inhibition of autophagy significantly enhances combination therapy with sorafenib and HDAC inhibitors for human hepatoma cells[J];世界胃肠病学杂志(英文版);2014-17
8 Zeeshan Ramzan;Ammar B Nassri;Sergio Huerta;VA North Texas Healthcare System-Dallas VA Medical Center, University of Texas Southwestern Medical Center, Dallas, TX 75216, United States;;Genotypic characteristics of resistant tumors to pre-operative ionizing radiation in rectal cancer[J];世界胃肠肿瘤学杂志(电子版)(英文版);2014-07
9 DOU Xiaofeng;ZHANG Yafei;CHEN Qiang;LI Wenjiao;LI Yang;YU Chundong;SU Xinhui;Department of Nuclear Medicine,First Affiliated Hospital,Xiamen University;State Key Laboratory of Cellular Stress Biology,School of Life Sciences,Xiamen University;;Down-regulation of TSPO expression doesn't affect the productions of TNF-α,IL-1β and IL-6 in LPS-stimulated BV-2 microglia[J];Chinese Journal of Cellular and Molecular Immunology;2014-09
10 Kerstin Schütte;Christian Schulz;Alexander Link;Peter Malfertheiner;Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke-University of Magdeburg;;Current biomarkers for hepatocellular carcinoma: Surveillance, diagnosis and prediction of prognosis[J];世界肝病学杂志(电子版)(英文版);2015-02
【Secondary Citations】
Chinese Journal Full-text Database 3 Hits
1 LIU Chun-ling,JIANG Jia-yu,YANG Shun-e.Xinjiang Medical University,Xinjiang Urumqi 830011,China.;A study on the relationship between serum level of VEGF and its expression in tumor tissue of NSCLC[J];Journal of Modern Oncology;2004-06
2 Zhou Baosen; Liu Keli; He Anguang;et al(Lung Cancer Laboratory,Cancer Institute, China Medical University, Shenyang,110001);The Study on the Risk and PAR of Cigarette Smoking to Lung Cancer[J];JOURNAL OF CHINA MEDICAL UNIVERSITY;1996-01
3 HONG Jian1,ZOU Ru-hai2,YANG Long-jun1,LI Bin-kui1,HUANG Pin-zhu1,YUAN Yun-fei1*(1.Department of Hepatobiliary Oncology,2.Department of Ultrasound,Key Laboratory of Oncology in South China//Cancer Center of Sun Yat-sun University,Guangzhou 510060,China);Prognostic Significance of Full-length SYK Expression in Human Hepatocellular Carcinoma[J];Journal of Sun Yat-Sen University(Medical Sciences);2011-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved