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《Journal of Sun Yat-sen University(Medical Sciences)》 2014-01
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Relationship between Condition of Hypoxia and Tumor Angiogenesis and Prognosis in Patients with Renal Carcinoma

ZHUANG Wei;LI Yi-ning;CHEN Jia-bi;HE Qing-liu;Department of Urology,The Second Affiliated Hospital of Fujian Medical University;  
【Objective】To explore the difference of tumor angiogenesis and postoperative survival between condition of hypoxia patients and general patients with renal clear cell carcinoma, and assess the status and mechanisms of condition of hypoxia in the patients with the renal clear cell carcinoma. 【Methods】 Fifty-six cases of renal clear cell carcinoma with radical nephrectomy surgery were divided into condition of hypoxia group(OH group, 14 cases) and condition of normoxia group(NS group, 42 cases). Immunohistochemical detection of hypoxia inducible factor-1ɑ(HIF-1ɑ) of surgical specimens and measure of microvessel density(MVD) with CD105 flag. To follow up survival time and contrast the difference of clinical and pathological data in two groups, and the survival rate in two groups was evaluated by Kaplan-Meier method. And the COX model was build to analyze the correlation between each variable and survival time. 【Results】 In OH group, the positive expression rate of HIF-1ɑ was 92.9%(13 / 14) and the MVD value was 53.1±19.9, median survival time was 42.0±10.2 months. In NS group, the positive expression rate of HIF-1ɑ was 64.3%(27 / 42), and the MVD value was 42.8 ±14.4, median survival time was 84.0 ±6.1 months. In two groups, Hb level, HIF-1ɑexpression, MVD value were significantly different. COX multivariate analysis showed that high stage, organism hypoxia, high expression of HIF-1ɑ and high MVD in tumor can increase the risk of death(RR followed were 2.0, 4.1, 1.1, and 4.0). 【Conclusion】 Condition of hypoxia may exacerbate hypoxia within the tumor, increasing HIF- 1ɑ expression, and promote tumor angiogenesis, eventually worsen the prognosis in the patient with renal clear cell carcinoma.
【Fund】: 福建省泉州市科技计划项目[泉科(2011)117号]
【CateGory Index】: R737.11
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