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《Journal of Sun Yat-sen University(Medical Sciences)》 2014-01
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Predictive Value of Serum DHEAS Level for Poor Ovarian Response and Pregnant Outcome in IVF-ET Cycles

GUO Jing;ZHANG Qing-xue;LI Yu;HUANG Jia;WANG Wen-jun;HUANG Li-li;ZHAO Xiao-miao;YANG Dong-zi;Reproductive Center,The Second Affiliated Hospital,Sun Yat-sen University;  
【Objective】 This study aimed to estimate the predictive value of serum dehydroepiandrosterone sulphate(DHEAS) level in early follicle phase for poor ovarian response and negative pregnancy outcome in IVF-ET treatment. 【Methods】 This was a retrospective study in single centre. 1208 Chinese women aged 20-44 years undergoing the first cycle of IVF / ICSI-ET. Patients with polycyctic ovarian syndrome were exclude. All patients received standard ovarian stimulation under pituitary suppression with GnRH agonist. Main outcome measures included 1) serum FSH, LH, total testosterone(T), estradiol(E2) and DHEAS levels on Day 3 of the menstrual cycle before treatment cycle; antral follicle count(AFC) and mean ovarian volume(MOV) were obtained from transvaginal sonography; 2) ovarian stimulation parameters and pregnancy outcome. 【Results】 DHEAS concentration had no noticeable difference among age-related groups. DHEAS level had no association with basal FSH, FSH / LH, E2, AFC, Mov, oocytes yield and IVF pregnancy outcome in patients younger than 35 years old. DHEAS negatively correlated with basal FSH in patients with 35≤aged40(r =-0.28, P = 0.011). DHEAS level was significantly lower in patients with POR than non-POR, and significantly higher in pregnant patients than non-pregnant patients. DHEAS was a preferable predictor with an ROC-AUC of 0.838 and a threshold of 2.58 μmol / L(a sensitivity of 85.7% and a specificity of 85%, respectively) for poor ovarian response in patients 35≤aged≤44(OR 0.998; 95%CI 0.996-0.999; P = 0.023), but not a reliable predictor for pregnancy outcome(ROC-AUC was 0.662, P = 0.04). 【Conclusion】 Our data suggest that serum DHEAS, as a single parameter, is a preferable predictor for poor ovarian response in older patients(35≤aged≤44), but it is not a reliable predictor for pregnancy outcome. Future studies need to identify whether patients who are potential poor ovarian responders and with low levels of DHEAS in this subgroup women could get benefit from exogenous DHEA supplementation.
【Fund】: 2010年卫生部临床重点学科项目(2010439)
【CateGory Index】: R714.7
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【References】
Chinese Journal Full-text Database 1 Hits
1 Chen Gang;Zhou Yu;Department of Radiology,Guizhou Aerospace Hospital;;Multi-layered screw CT coordinated by transvaginal ultrasound for evaluating relationship between polycystic ovarian syndrome induced ovulatory obstacle and level of dehydroepiandrosterone sulfate[J];现代医药卫生;2015-18
【Co-references】
Chinese Journal Full-text Database 1 Hits
1 GUO Jing;ZHANG Qing-xue;LI Yu;HUANG Jia;WANG Wen-jun;HUANG Li-li;ZHAO Xiao-miao;YANG Dong-zi;Reproductive Center,The Second Affiliated Hospital,Sun Yat-sen University;;Predictive Value of Serum DHEAS Level for Poor Ovarian Response and Pregnant Outcome in IVF-ET Cycles[J];中山大学学报(医学科学版);2014-01
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