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《Journal of Sun Yat-sen University(Medical Sciences)》 2016-01
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Second-trimester Maternal Serum Lipids Metabolism in Women with Hypertensive Disorders Complicating Pregnancy

DENG Song-qing;LIU Bin;WANG Zi-lian;Department of Obstetrics and Gynecology,The First Affiliated Hospital,Sun Yat-sen University;  
【Objective】 To study maternal serum lipids characteristic during second-trimester in hypertensive disorders complicating pregnancy and normotensive pregnant women. 【Methods】 A total of 1762 pregnant women who underwent obstetric examination in Sun Yat-sen University First Affiliated Hospital between January 2013 to November 2013 were analyzed retrospectively, including hypertensive disorders complicating pregnancy(n = 77) and normotensive pregnant control(n=1685).Triglycerides(TG), high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein cholesterol(LDL-C), total cholesterol(TC), apolipoprotein A1(apo A1), apolipoprotein B(apo B), apolipoprotein E(apo E), lipoprotein a(Lp(a)) were measured in gestational age of 24-28 weeks. 【Results】 Women with hypertensive disorders complicating pregnancy had significant higher body mass index(BMI) when serum lipids test taken(25.38 ± 3.17 vs 23.76 ± 2.74,P 0.001). Women with hypertensive disorders complicating pregnancy exhibit higher serum TG levels compared with normotensive pregnant women(2.48 ± 1.11 mmol / L vs 2.12 ±0.77 mmol / L,P = 0.007).Whereas LDL-C(3.08 ± 0.88 mmol / L vs 3.32 ± 0.84 mmol / L, P=0.018) and HDL-C(1.73 ± 0.38 mmol /L vs 1.85 ± 0.34 mmol / L, P = 0.004) were lower. TC, apo A1, apo B, apo E, Lp(a) did not differ significantly in the two groups.Logistic regression revealed that BMI(OR =1.172,95%CI 1.082 to 1.271,P 0.001)and TG(OR = 1.395,95%CI 1.083 to 1.796,P= 0.010) were risk factor for hypertensive disorders complicating pregnancy. ROC curve demonstrated 0.706 AUC on the joint predictive factor of TG, LDL-C, BMI and gestational age. 【Conclusion】 Obesity and hypertrigliceridemia during second-trimester pregnancy were risk factor for hypertensive disorders complicating pregnancy, and the combined data have prediction value for hypertensive disorders during pregnancy.
【Fund】: 中山大学“5010”临床研究项目(2012004)
【CateGory Index】: R714.246
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 XU Li-nan,WANG Zi-lian,HE Ke,ZHANG Ying,CAI Jian,YANG Jian-bo,ZHOU Can-quan(Department of Obstetrics and Gynecology,The First Affiliated of Hospital,Sun Yat-sen University,Guangzhou 510080,China);Differential Lipid Metabolism-related Genes in Patients with Hypertensive Disorder Complicating Pregnancy[J];中山大学学报(医学科学版);2011-04
【Co-citations】
Chinese Journal Full-text Database 1 Hits
1 QI Lei;Department of Obstetrics and Gynecology,Anyue County People's Hospital;;Detection and clinical significances of serous oxidized lowdensity lipoprotein in preeclampsia[J];中国医药科学;2013-15
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