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《Journal of Sun Yat-sen University(Medical Sciences)》 2016-06
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Factors Associated with Exercise Capacity in Stable Chronic Obstructive Pulmonary Disease Patients

LIN Lin;TIAN Jing-wei;ZHUAN-SUN Yong-xun;LI Jian-guo;CHEN Rui;Department of Respiration,Sun Yat-sen Memorial Hospital, Sun Yat-sen University;Comprehensive Department, Sun Yat-sen Memorial Hospital, Sun Yat-sen University;  
【Objective】To investigate the important factors for exercise capacity in patients with stable chronic obstructive pulmonary disease(COPD). 【Methods】A total of 109 consecutive subjects with stable COPD underwent a six-minute walk test(6MWT), while inspiratory capacity(IC) was recorded before and immediately after walking. Spirometry, quadriceps muscle function, the Modified Medical Research Council(m MRC) dyspnea scale, St George's Respiratory Questionnaire(SGRQ),Pittsburgh Sleep Quality Index(PSQI), Epworth Sleeping Scale(ESS), Hamilton Anxiety Scale(HAMA) and Hamilton Depression Scale(HAMD) were also assessed. 【Results】Multiple stepwise regression analysis was performed to identify that the significant predictors of six- minute walk distance( 6MWD) were age( standardized coefficient β =- 0. 264, P = 0. 007), HAMD score(β =-0.246, P = 0.005), SGRQ activity score(β =-0.194, P = 0.029) and strength in quadriceps muscle(β = 0.197, P = 0.030).【Conclusion】Age, depression, physical activity in daily life and strength in quadriceps muscle may be the major factors associated with functional exercise capacity in patients with stable COPD.
【Fund】: 广东省科技计划项目(2011B080701062);; 广东省自然科学基金(S2012010008623)
【CateGory Index】: R563.9
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