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《ACADEMIC JOURNAL OF SUN YAT-SEN UNIVERSITY OF MEDICAL SCIENCES》 1997-01
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MODEL OF BRAIN STEM MECHANICAL INJURY IN THE RATS

Zhou Wei Xu Xiaohu Zhu Jiazhen (Department of Forensic Pathology, Sun Yat sen University of Medical Sciences, Guangzhou, 510089)  
Brain stem injury model was sucessfully produced in rats by hitting the occipitial protuberance with a strip of steel. The indexes include: Hitting resulted in immediate coma, loss of corneal reflex, startle reflection and pain reflection; the animals died within 3 hours after hitting; gross obersvation shows no skull fracture, no or a little subarachnoid hemorrhage, no cerebral contusion, only a few small spotty hemorrhages in brain stem in some cases. Light microscopic survey shows only minor pathologies, such as spotty hemorrhage and brain stem edma. The elastic force that produces rats' brain stem injury is 1.6 ̄2 N. When the force surpasses 2 N, it can be applied for making the model of extensive craniocerebral injury; As the force is less than 1.6 N, it may cause brain concussion.
【Fund】: 国家自然科学基金
【CateGory Index】: D919.1
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