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《Chinese Journal of Veterinary Medicine》 2004-01
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Effect of some cytokines on placenta maturation in the small fat tail sheep

GE Li-jiang~1,TIAN Wen-ru~2,CUI Lin~1, WANG Xue-dong~1,CHEN Yu-xin~1,FAN Xiu-jun~3(1.Heilongjiang Aug.1~(st) Land Reclamation University, Mishan 158308, China; 2.Northeast Agricultural University, Harbin 150030, China)  
To study the effect of some cytokines on placenta ripening in small-tail winter sheep, we utilize liquid-phase competition method and equilibrium method to measure the contents of serum interleukin 1β and 6 (IL-1β and IL-6), and tumour necrosis factor (TNF) in nonpregnant sheep (n=5) and sheep at day 85,105,125 and 140 after gestation and 150 (at parturition) (n=13). The results show that the content of serum IL-1β and IL-6 in sheep at day 125 after gestation are significantly higher than one in nonpregnant sheep (in control) (P0.01), and the contents of serum TNF at every periods during mid and hate pregnancy are higher than one in control(P0.01 or P0.05). As pregnant period onwards, the level of three cytokines in serum increases gradually and reachs to peak value at day 125 after gestation. It is suggested that there is close relationship between cytokines and gestation and cytokines have important role in maintaining gestation. As the level of serum cytokines appears stable at day 140 after gestation and 150 (at parturition), it is showed that placenta has ripened at almost day 140 and it is possible that TNF has an important role in parturition, but IL-1β and IL-6 have no effect on it.
【CateGory Index】: S826.1
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