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《Chinese Journal of Veterinary Medicine》 2012-01
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Therapeutic efficacy of hypericin powder for chickens infected with infectious bursal disease virus

SHANG Ruo-feng,LIU Yu,CHEN Jiong-ran,GUO Wen-zhu,GUO Zhi-ting,LIANG Jian-ping (Key Laboratory of New Animal Drug Project,Key Laboratory of Veterinary Pharmaceutics Discovery,Ministry of Agriculture,Lanzhou Institute of Animal Science and Veterinary Pharmaceutics,Chinese Academy of Agricultural Sciences,Lanzhou 730050,China)  
Hypericin was proved to be the most active compound in Hypericum Perforatum.In order to evaluate the therapeutic effect of Hypericin powder against Infectious Bursal Disease(IBD),20-day-old chickens were infected with Infectious Bursal Disease Virus(IBDV BC-6/85) and then treated by oral administration with Hypericin powder for 4 days.The observation of pathological change index and isolation of the virus were performed to assess in vivo whether Hypericin would be a promising drug for IBD's treatment.The results showed that Hypericin powder effectively treated IBD with a dosage of 667.9 mg/kg b.w.for 4 days,and the therapeutic effect of the drug was better than egg yolk antibody.
【Fund】: “十一五”国家科技支撑项目“安全环保型中兽药的研制与应用”(2006BAD3IB05)
【CateGory Index】: S858.31
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 ZHOU Ji yong, LI Jian rong (Institute of Preventive Veterinary Medicine,Zhejiang University, Hangzhou 310029, China);Genetic Stability and Immunogenicity of Attenuated Infectious Bursal Disease Virus Variants[J];CHINESE JOURNAL OF VETERINARY SCIENCE;2000-04
【Co-citations】
Chinese Journal Full-text Database 9 Hits
1 LI He-lin~(1),ZHANG Hao~(1),JIAO Tie-jun~(1),LI Jian-qiang~(1,2) (1.Yangling Lufang Bio-engineering CO,LTD, Yangling,Shaaxi, 712100, China; 2.Northwest A&F University,Yangling,Shaanxi,712100,China);Attenuation of Infectious bursal disease virus X-28 Strain and its Pathogenicity[J];Progress In Veterinary Medicine;2005-08
2 SHANG Ruo-feng1,LIANG Jian-ping1,HE Cheng2,LIU Yu1,GUO Zhi-ting1,GUO Wen-zhu1,WANG Ling1,HUA Lan-ying1 (1. Lanzhou Insititute of Animal Husbandry & Veterinary Pharamaceutics Science/Key Laboratory of New Animal Medicine Project, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China; 2.College of Veterinary Medicine, China Agriculture University, Beijing 100091, China);Prevention Effect of Hypericin Powder Against IBDV in Chickens[J];Hubei Agricultural Sciences;2010-10
3 WANG Xue-bin,WEI Zhan-yong,CUI Bao-an,HU Mei,XU Duan-hong(Engineering College of Animal and Vetrinary Science,Henan Agricultural University,Zhengzhou 450002,China);The Anti-avian Virus Effect of Traditional Chinese Herbal Medicine Compound in Vitro[J];Journal of Henan Agricultural Sciences;2007-08
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【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 Zhou Jiyong,Ye Weicheng,Yu Lian (College of Animal Science Zhejiang University,Hangzhou 310029,China);ISOLATION AND IDENTIFICATION OF VARIANT STRAINS OF INFECTIOUS BURSAL DISEASE VIRUS IN ZHEJIANG PROVINCE[J];CHINESE JOURNAL OF ANIMAL AND VETERINARY SCIENCES;1999-06
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