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《Chinese Journal of Veterinary Medicine》 2012-01
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Therapeutic efficacy of hypericin powder for chickens infected with infectious bursal disease virus

SHANG Ruo-feng,LIU Yu,CHEN Jiong-ran,GUO Wen-zhu,GUO Zhi-ting,LIANG Jian-ping (Key Laboratory of New Animal Drug Project,Key Laboratory of Veterinary Pharmaceutics Discovery,Ministry of Agriculture,Lanzhou Institute of Animal Science and Veterinary Pharmaceutics,Chinese Academy of Agricultural Sciences,Lanzhou 730050,China)  
Hypericin was proved to be the most active compound in Hypericum Perforatum.In order to evaluate the therapeutic effect of Hypericin powder against Infectious Bursal Disease(IBD),20-day-old chickens were infected with Infectious Bursal Disease Virus(IBDV BC-6/85) and then treated by oral administration with Hypericin powder for 4 days.The observation of pathological change index and isolation of the virus were performed to assess in vivo whether Hypericin would be a promising drug for IBD's treatment.The results showed that Hypericin powder effectively treated IBD with a dosage of 667.9 mg/kg b.w.for 4 days,and the therapeutic effect of the drug was better than egg yolk antibody.
【Fund】: “十一五”国家科技支撑项目“安全环保型中兽药的研制与应用”(2006BAD3IB05)
【CateGory Index】: S858.31
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