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《Chinese Journal of Veterinary Medicine》 2012-01
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Influence of CSA combined with TobraDex in A eye drops on immunological rejection after high-risk corneal transplantation in dogs

XU Hui-hao1,2,XIAO Rong1,WU Bai-qing,LI Quan-lei1, YOU Bin-jie3,XU Mao-sen1,LI Jian1,ZHENG Xiao-bo1 (1.Department of Veterinary Medicine,Rongchang Campus of Southwest University,Rongchang 402460,China;2.Chongqing Friendship Animal Hospital,Jiangbei 400020,China; 3.Institute of Animal Science,Chongqing Academy of Animal Sciences,Rongchang 402460,China)  
To explore the curative effect of CSA combined with TobraDex eye drops on immunological rejection after high-risk penetrating keratoplasty(PKP) in canis.30 local dogs were chosen to be burnt as high-risk Pathological model and to be PKP.All of them were randomly average divided into two groups: normal saline group and CSA+TobraDex group.Each of them had 15 dogs which were treated by eye drop at the second day after PKP and kept the eye drops 6 times/day and 2 drops/each time.Medication group used different eye drops alternately,2 hours/period time.To observe immune rejection and the structure of cornea after PKP,we took the intraocular pressure examination.,histopathologic examination and slit-lamp examination.The result showed that the rejection time of medication group and normal saline group was 49.33±9.61 day,10.83±2.93 day respectively.The difference between these two groups was very significant(P0.01).The IOP of all the dogs were in the normal range(10~20 mmHg) at days after PKP.The structure of Cornea organization in normal saline group was changed and destroyed.The structure of cornea in medication group was normal during the whole observation period.
【CateGory Index】: R779.65
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