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《Chinese Journal of Veterinary Medicine》 2012-08
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Effects of the specifically antagonistic agent of XFM on NO,NOS,SOD and MDA in serum of miniature pigs

JIANG Sheng,YU Shi-ming,TAN Li-juan,FAN Hong-gang,WANG Hong-bin(College of Veterinary Medicine,Northeast Agricultural University,Harbin 150030,China)  
This experiment was conducted to study the degree of oxidative damage and the specificity effect of the Specifically Antagonistic Agent of XFM.14 Chinese experimental miniature pigs were anaesthetized with XFM intramuscularly and assigned to the experimental group and the control group randomly.Afer thirty minutes,the experimental group was awaked with the Specifically Antagonistic Agent of XFM,but the control group was administered with saline at the same dosage with the experiment group.Concentrations of NO,NOS,SOD,MDA in serum of Miniature Pigs were detected.Recovery time to aural,eyelid,pedal and tail clamp reflexes after administrations of the Specifically Antagonistic Agent of XFM were significantly shortened in the experimental group when compared with the control group.Concentrations of MDA,SOD in serum were no significant differences.Concentrations of NO,NOS were significantly different in comparison with the blank or thirty minutes after injection of XFM,however concentrations of NO,NOS gradually incyeased and there were no significant differences sixty minutes after injection of XFM as compared to the control.The Specifically Antagonistic Agent of XFM are much more effective for antagonising the anaesthesia and no oxidative damage were found.
【Fund】: 国家自然科学基金项目(30671552 30972227);; 黑龙江省研究生创新科研项目(YJSCX2011-083HLJ)
【CateGory Index】: S859.79
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