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Clinical application of plasma thrombomodulin measurement

Zhou Weili,Wang Xuefeng,Wang Xiaowei,et al. Rui Jin Hospital,Shanghai Secondary Medical University,200001.  
bjective To study the clinical significance of thrombomdulin as a molecular marker indicating vascular endothelium injury.Methods Plasma concentration of thrombomodulin(TM) were measured in patients with acute leukemia(AL),diabetes mellitus(DM) and liver disease.Results The results showed that ①Plasma level of TM significantly increased in AL group and decreased after remission.However,no marked difference was detected between ANLL and ALL group.②Plasma level of TM was noteworthily elevated,with higher level in microangiopathy group than that in nonmicroangiopathy group.45% of the latter group appeared higher comparing the normal control.③Plasma level of TM also increased remarkably in liver disease patients,except in acute hepatitis group.The levels of acute fatal hepatitis and decompensated liver cirrhosis group were higher than those in acute hepatits and compensated liver cirrhosis group respectively.Conclusion Different degree of vascular endothelial cell injury exists in these patients,and measurement of plasma thrombomodulin is useful in predicting procession of the diseaese.
【CateGory Index】: R446
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