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Hyperthermia nebulization of 5Fu in lung cancer :Laboratory study

Xu Luping,Wang Jianzhong,Li Haibin,Department of Thoracic Surgery,Affiliated Hospital,Jilin Medical Collega,Jilin 132001  
bjective A new method combining thermotherapy and chemotherapy was established through hyperthermal aerosol inhalation of 5fluorouracil(5Fu) to treat lung cancer.Methods The subjects of experiment were rabbits and patients with lung cancer.In order to compare hyperthermal aerosol in halation of 5Fu with ordnary aerosol inhalation and intravenous chemotherapy,the content of 5Fu in trachea,hilar bronchi,lung tissue surrounding the tumor,hilar lymph nodes,tumor tissue and plasma were determined with HPLC.Pathologic examination was also performed.Results Hyperthermal aerosol inhalation can significantly increase the contents of 5Fu in the tissues mentioned above(P001).No acute damage to lung tissue was found in pathologic examination of lung tissues.Conclusion Thermotherapy and local chemotherapy via aerosol inhalation can be used simultaneously with synergistic effect and there is no obvious general toxic side effect.
【Fund】: 吉林省教委科研基金
【CateGory Index】: R734.2
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