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《Chinese Journal of Gastrointestinal Surgery》 2002-04
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Cyclooxygenase-2 expression in human colorectal cancer and its relationship with tumor angiogenesis

WU Aiwen,GU Jin,LI Zhenfu,et al. Department of Surgery,School of Oncology,Beijing Institute for Cancer Research,Beijing Cancer Hospital,Peking University,Beijing 100036,China  
Objective To investigate the expression of cyclooxygenase 2(Cox 2) and its relationship with VEGF expression in colorectal cancer. Method RT PCR was used to detect the expression of Cox 2 and VEGF in 35 patients with colorectal cancer during February to September 2001, and correlation of Cox 2 with biological characteristics of colorectal cancer was analyzed. Results (1)80% of the tumor tissues, while 31 4% of normal tissues, were Cox 2 positive (P 0 01). (2) The positive rate of Cox 2 expression in tumors with a diameter of 3~6 cm was higher than that more than 6 cm (P=0 0334). (3)Cox 2 expression increased in high differentiation tissues as compared to middle and low differentiation tissues, its expression in stage A/B colorectal cancer was higher than that in stage C/D, but no significance was found(P 0 05). (4)VEGF expression in Cox 2 positive group was significantly higher than that in Cox 2 negative group (P=0 0030). Conclusion 80% of colorectal cancer tissues expressed Cox 2 and its expression is correlated with tumor size and VEGF expression.
【CateGory Index】: R735.3
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