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《Chinese Journal of Gastrointestinal Surgery》 2002-04
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Clinical significance of E-cadherin and α-catenin expression in colorectal cancer

DONG Quanjin,ZOU Shouchun,DENG Gaoli, et al. Department of Coloproctological Surgery,Zhejiang Provincial Peoples Hospital,Hangzhou 310014,China  
Objective To examine the expression of E cadherin(E CD) and α catenin(α cat) in colorectal cancer tissues and,to evaluate its relationship with clinicopathological features of colorectal cancer. Methods Expression of E CD,α cat was examined in 10 normal colorectal mucosas,19 colorectal adenomas, and 115 colorectal cancers by immunohistochemical method(EnVision), and relationship of the expression of E CD and α cat with infiltration, metastasis and prognosis in colorectal cancer were analyzed. Results All the normal colorectal mucosas epithelium(10/10) expressed E CD,α cat as preserved. For colorectal adenomas, preserved expression of E CD, α cat was reduced. For colorectal cancers, 21 7% expressed E CD as preserved, 42 6% expressed α cat as preserved. The expression patterns of E CD,α cat were significantly correlated with survival rate of colorectal cancer patients (P 0 01). Conclusions The reduced expression of E CD, α cat indicates advanced cancer and poorer prognosis. α cat expression type in tumor epithelium is an independent prognostic predictor of colorectal cancer patients.
【CateGory Index】: R735.3
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【References】
Chinese Journal Full-text Database 2 Hits
1 Che Xiangming, Wang Shufeng, Wang Kang, Sheng Wei, Liu Xiaoyi (Department of General Surgery, First Hospital of Xi'an Jiaotong University, Xi'an 710061, China);The expression of E-cadherin and its relation with invasive ability of basal membrane in tumor cells[J];Journal of Xi'an Jiaotong University(Medical Sciences);2004-03
2 CHE Xiang-ming,WANG Shu-feng,FAN Lin,ZHANG Ru-yuan,ZHAO Wei.Department of General Surgery,The First Hospital,Xi'an Jiaotong University,Xi'an 710061,China;Study of E-cadherin Antisense Oligodeoxynucleotide on Invasive Ability of Tumor Cells[J];Chinese Journal of Bases and Clinics in General Surgery;2006-02
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 MA Qing Yong, DONG Bo Department of Hepatobiliary Surgery, First Hospital, Xi’an Jiaotong University, Xi’an 710061, China;Expression of MMP-2 and TIMP-2 in human pancreatic carcinoma and its clinical significance[J];Journal of The Fourth Military Medical University;2004-01
2 WANGChunhui, TANG Chengwei, TANG Liping. Department of Gastroenterology, The West China Hospital of Sichuan University, Chengdu (610041);Inhibitory Effect of Octreotide on the Growth of Gastric Cancer in vivo and in vitro[J];Chinese Journal of Gastroenterology;2002-03
3 GUO Xiaozhong, Friess H, XU Jianhua , et al. Department of Gastroenterology, Shenyang General Hospital of PLA , Shenyang 110016, China;Analysis of KAI1 Gene Mutations in Pancreatic Cancer[J];Chinese Journal of Pancreatology;2001-01
4 Chen Fuzhen+*,Ge Xiaohu,Zhao Dajian,et al.+*Zhongshan Hospital,Fudan University,Shanghai 200032,China;Problems of vascular reconstruction combined pancreatoduodenectomy:report of 42 cases.[J];Chinese Journal of Practical Surgery;2002-05
5 XU Jian-hua, GUO Xiao-zhong, REN Li-nan, et al. Department of Gastroenterology, General Hospital of Shenyang Military Region, Shenyang 110016, China;The studies on the role of KAI1 gene in anti-metastasis of primary pancreatic cancer cells[J];Chinese Journal of Digestion;2004-09
6 GONG Shi-wen*,MIN Jun,CHEN Ya-jin,OU Qing-jia,CHEN Tao,CHU Zhong-hua,QIAN Shi-kun,LIANG Hui-zhen. *Department of Surgery, Second Affiliated Hospital, Sun Yat-sen University, Guangzhou 510120,China;The effect of somatostatin on expression of metalloproteinase-2 and tissue inhibitor matrix metalloproteinase-2 of implanted liver tumor after partial hepatectomy in nude mice[J];Chinese Journal of General Surgery;2004-05
7 WANG Chunhui, TANG Chengwei, TANG Liping. Department of Gastroenterology , The First Hospital, Chongqing University of Medical Sciences, Chongqing, 400016 China;Inhibition effects of octreotide on the growth of hepatocellular carcinoma in vitro and in vivo[J];National Medical Journal of China;2001-19
8 He Shuangwu, Zhao Yanming, Shen Kangqiang. Department of General Surgery, Daping Hospital and Research Institute of Surgery, Third Military Medical University,Chongqing 400042;THE EFFECT OF SOMATOSTATIN ON THE TRANSPLANTED HUMAN COLONIC CARCINOMA AND ITS MECHANISM IN GYMNOMOUSE BODY[J];CHINESE JOURNAL OF BASES AND CLINCS IN GENERAL SURGERY;1999-01
9 LIU Zheng-ren,WU Gao-song,DU Zhi-yong,WANG Da-yu,QIN Ren-yi,QIU Fa-zu(Department of General Surgery,Tongji Hospitol,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China);Effect of octreotide on pancreatic cancer cells transfected with SST 2 gene[J];Chinese Journal of General Surgery;2004-06
10 FENG Yan-ping,HUANG Tao,GAO Jun,QIN Ren-yi(Department of Pancreatic-Biliary Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan430030,China);Expression and significance of EphA2 and E-cadherin in pancreatic carcinoma[J];Chinese Journal of General Surgery;2005-12
【Secondary References】
Chinese Journal Full-text Database 6 Hits
1 LIU Gang,ZHANG Zhi-xiang,TIAN Wei-jun,ZHU Li-wei,WANG Peng-zhi(Department of General Surgery,General Hospital,Tianjin Medical University,Tianjin 300052,China);Expression and clinical significance of E-cadherin in hepatocellular carcinoma[J];Journal of Tianjin Medical University;2007-01
2 ;应用组织芯片研究E-cadherin在大肠癌的表达[J];Chinese Journal of Pathophysiology;2007-07
3 MA Jun-jun,FENG Bo, ZHANG Yi, LU Ai-guo, HU Wei-guo,LI Jian-wen,WANG Ming-liang,ZHENG Min-hua.Department of General Surgery,Ruijin Hospital,Shanghai Jiaotong University,School of Medicine,Shanghai Minimally Invasive Surgery Center,Shanghai Institute of Digestive Surgery,Shanghai 200025,China;Effect of CO_2-Insufflation on Invasion Capacity of Colon Cancer Cells in Vitro[J];Chinese Journal of Bases and Clinics in General Surgery;2007-05
4 LI Hong*,SHU Yi *,CHEN Yong-jun*,ZOU Sheng-quan*.*Department of Biliary and Pancreatic Surgery,Affiliated Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Effects of DNA Methyltransferase Inhibitors and Histone Deacetylase Inhibitors on Expression of E-cadherin and Invasion of Cholangiocarcinoma Cell[J];Chinese Journal of Bases and Clinics in General Surgery;2009-01
5 YAO Yong-zhong,PAN Yi-ming,SUN Xi-tai,QIU Yu-dong,DING Yi-tao.Department of General Surgery,Affiliated Drum Tower Hospital of Medical College of Nanjing University,Nanjing 210008,China;Expression and Function of CD105 in Angiogenesis[J];Chinese Journal of Bases and Clinics in General Surgery;2009-10
6 HUANG Wen-qing1,YANG Wen-li1,CHAI Xin-juan1,CHEN Ke-fei2,WEI Ling1,LI Bo2,QIN Yang1.1.Department of Biochemistry and Molecular Biology,School of Preclinical and Forensic Medicine,West China Medical Center,Sichuan University,Chengdu 610041,Sichuan Province,China;2.Department of Hepatic Surgery and Vascular Surgery,West China Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China;Aberrant Promoter CpG Islands Methylation of E-cadherin in Human Primary Hepatocellular Carcinomas[J];Chinese Journal of Bases and Clinics in General Surgery;2011-05
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