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《Women's Health Research》 2017-04
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Expression of Smac and Xiap in placentae in preeclampsia

Zhao Taikun;Hai Jujun;Tan Yujie;Li Xicong;The Hospital Affiliated to Zhengzhou University Center of Luoyang;  
Objective:To study the expressions of the mitochondrial protein Smac,antiapoptotic gene Xiap in placentae in preeclampsia.Methods:120samples(normal pregnancies=40,early onset preeclampsia=40,late onset preeclampsia=40)were collected from apparently normal tissue and areas.The expressions of Smac,Xiap were measured by Immunohistochemical SP method.The relativity analysis were performanced.Results:1)Smac,Xiap were mainly expressed in trophoblast cytoplasm.2)The expressions of Smac protein(25.35±1.63)and(24.55±2.21)in placentae in early,late onset preeclampsia were significantly higher than that in control group(18.32±0.21),moreover,the early onset was higher compared to late onset group(P 0.05).3)The expressions of Xiap proteinin(20.54±0.96)、(26.18±0.09)in placentae in early late preeclampsia were significantly lower than that in control group(31.24±1.76),moreover,the early onset was lower compared to late onset group(P 0.05).4)The expression of Smac and Xiap were negatively correlated(P 0.05).Conclusion:The abnormal expression Smac,Xiap may contribute to the occurrence of preeclampsia and is related to the result of the pregnancy.
【CateGory Index】: R714.246
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