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《Women's Health Research》 2017-23
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Long-term use of clozapine combined with classical antipsychotic drugs' effect on patients' body weight,glucose metabolism,and lipid

He Hua;Department of Psychiatry,Rugao Psychiatric Hospital;  
Objective:To investigate the long-term use of clozapine combined with classical antipsychotic drugs' effect on schizophreniac's body weight,glucose metabolism and blood lipid.Methods:156 cases of patients who were diagnosed with schizophreniac and received treatments in our hospital from January 2015 to July 2016 were chosen as the research object,and divided into classical antipsychotic group,clozapinegroup and combined treatment group,54,50,52 cases in each group.Compare the related index on body weight,glucose metabolism and blood lipid between the three groups.Compare the incidence rate of diabetes andimpaired glucose tolerance between different groups.Results:The BMI,GLU,TG,FFA of the combined treatment group were higher than the classical antipsychotic group,with significant difference(P 0.05),the FINS,HOMA-IR index of the combined treatment group were significantly higher than that of the classical antipsychotic group and clozapine group(P 0.05),the clozapine group had higher TC level than the classical antipsychotic group,with significant difference(P 0.05).The incidence of diabetes and impaired glucose tolerance of the combined treatment group and clozapine group were higher than it in the classical antipsychotic group,with significant difference(P 0.05).Conclusion:The long-term use of classical antipsychotic drugs combined with clozapine can lead to increased body weight,elevated fasting blood glucose,increased insulin secretion,increased corresponding blood lipid.More attention should be paid to it in clinical work.
【CateGory Index】: R749.3
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