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《植物学报(英文版)》 2003-05
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Polyhydroxylated Steroidal Sapogenins from Tupistra wattii

SHEN Ping 1, WANG San_Long 3, YANG Chong_Ren 2, CAI Bing 3, YAO Xin_Sheng 1 * (1. Shenyang Pharmaceutical University, Shenyang 110016; 2. Kunming Institute of Botany, The Chinese Academy of Sciences, Kunming 650204; 3. Beijing Institute of Biomedicine, Beijing 100091)  
Two novel polyhydroxylated steroidal sapogenins, wattigenin B ((25 R )_spirost_1β, 2β, 3β, 4β, 5β, 6β, 7α_heptol, 1) and wattigenin C ((25 S )_spirost_1β, 2β, 3β, 4β, 5β, 7α_hexahydroxyl_6_one, 2), together with two known sapogenins, kitigenin (3) and convallagenin B (4), were isolated from the fresh rhizomes of Tupistra wattii Hook. f. The structures of the compounds were determined on the basis of spectroscopic analysis. The four sapogenins were evaluated for the cytotoxicities on the cancer cell line K562 and A2780a in vitro. Compounds 1-4 were obtained from the plant for the first time.
【Fund】: 国家重点基础研究发展规划项目 (G19980 5 1113 ) ;; 植物化学与西部植物资源可持续利用国家重点实验室资助项目~~
【CateGory Index】: R284
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