Effect of Dopamine on renal microcirculatory perfusion measured by a laser doppler flowmeter in shock animals
Wang Xue Wen Department of Pathopqdhysiology, Shihezi Medical College Xinjiang
The effects of Dopamine on renal microcirculatory perfusion measured by a laser doppler flowmeter were studied in 44 hemorrhagic rats and 17 hemorrhagic rabbits. The results indi cated that at 5 and 20 min, after intravenous infusions of Dopamine(20ug or 40 ug/0.1 ml/100g B. W.) the renal perfusion signifcantly increased. The response to Dopamine was more sensitive in the young rats than that in the aged rats, 20 min, after intravenous infusion of Dopamine(100 μg/lml/lkg B. W.) the perfusion in renal cortex markedly increased. At same time it was found that the blood flow volume in left renal aetery no increased when it was measured by a square wave electromagnetic flowmeter. According to the results mentioned above, the author suggests that the mechanism of increase in renal microcirculation perfusion induced by Dopamine was probably related to the blood redistribution in renal microcirculation.