Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Reparative and Reconstructive Surgery》 2002-01
Add to Favorite Get Latest Update

EFFECT OF THE ENDOEXPANDER PRESSURE OF CONTINUOUS AND CONSTANT PRESSURE EXPANSION ON THE DRUG PERMEABILITY

ZHAN Wang, ZHU Fei, KUANG Li xiang, et al. Department of Plastic Surgery, Hainan Provincial Hospital. Haikou Hainan, P. R. China 570311. E mail: williamzhan@yeah.net  
Objective To investigate the effect of the endoexpander pressure of continuous and constant pressure expansion on the drug permeability. Methods The expanders were divided into two groups, the normal expansion and the continuous and constant pressure expansion (4.6 kPa). Each expander was filled with 0.2% Metronidazole, then the expanders were immersed wholly in normal saline and sealed totally. At several intervals over 72 hours, the surrounding saline was sampled and the drug concentration of the sample was measured respectively. Results Both groups were permeable to the Metronidazole and the concentration outside the expander would reach the effective concentration in 48 hours. The drug concentration of the continuous and constant pressure expansion was higher than that of the normal one and there was significant difference between the two groups ( P 0.01). Conclusion The endoexpander pressure in continuous and constant pressure expansion can enhance the drug permeability. In view of this, in the course of continuous and constant pressure expansion, 0.2% Metronidazole can be used to prevent and control the infection.
【Fund】: 海南省卫生厅科研基金资助项目 (琼卫 2 0 0 0 -5 8)
【CateGory Index】: R62
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved