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《Chinese Journal of Reparative and Reconstructive Surgery》 2015-01
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XIA Bo;TAN Meiyun;Department of Bone and Joint Surgery,the Affiliated Hospital of Luzhou Medical College;  
Objective To comprehensively analyze and compare the biological difference between bone marrow mesenchymal stem cells(BMSCs) and placenta-derived MSCs(PMSCs) in hypoxia and to extend the knowledge for seed cells selection. Methods The domestic and foreign related literature about the effects of hypoxia microenvironment on proliferation,apoptosis,differentiation,paracrine secretion,migration,and homing ability of BMSCs and PMSCs were summarized and analysed. Results PMSCs proliferated much faster and more sensitive to the hypoxia than BMSCs; in addition,PMSCs showed stronger survivability. Similar to BMSCs,PMSCs can home to hypoxic-ischemic tissues efficiently,secrete a lot of growth factors and differentiate into tissue-specific cells to stimulate tissue regeneration. Conclusion PMSCs as the seed cells will have broad application prospects in the regenerative medicine.
【Fund】: 国家自然科学基金资助项目(31271049)~~
【CateGory Index】: R329.2
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