Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Reparative and Reconstructive Surgery》 2015-01
Add to Favorite Get Latest Update


GUI Keke;YU Yonglin;Department of Orthopaedics,Jinshan Hospital,Fudan University;Department of Orthopaedics,Huashan Hospital,Fudan University;  
Objective To review the research status on the molecular basis of intervertebral disc degeneration and the repairing effect of platelet-rich plasma. Methods The related literature about the molecular basis of intervertebral disc degeneration and the repairing effect of platelet-rich plasma was reviewed,analyzed,and summarized. Results The molecular basis of intervertebral disc degeneration includes genetic influences,cell senescence,decreased matrix production,increased degradative enzyme production,proinflammatory cytokine expression,apoptosis,and neural ingrowth. Platelet-rich plasma can release a series of growth factors to promote intervertebral disc cells proliferation,differentiation,and extracellular matrix synthesis. It can also inhibit proinflammatory effect and apoptosis. Conclusion Although the prospect of using platelet-rich plasma to repair intervertebral disc degeneration is encouraging,further studies are still needed.
【Fund】: 上海市金山区科技创新基金项目(2012-3-05)~~
【CateGory Index】: R681.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 10 Hits
1 ZHAO Ying,TAN Zhu-jian,WU Xue-hui,et al.(Department of Orthopaedics,Southwest Hospital,Third Military Medical University,Chongqing 400038,China);Expression of matrix metalloproteinase-9 in lumbar intervertebral disc[J];Journal of Traumatic Surgery;2007-03
2 CHEN Fei,LI Kang-hua,LU Guo-hua. Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha 410011, China;The Effect of Human Placenta Lipopolysaccharide and Dexamethasone on Spontaneous Resorption of Herniated Intervertebral Disc[J];Journal of Chinese Physician;2005-03
3 WU Wei-ping1, JIANG Jian-ming2, QU Dong-bin2, WEI Qing-zhu1, JIANG Hui2 1Department of Spinal Surgery, Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China; 2Department of Orthopaedics and Spine Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China;Expression of hypoxia-inducible factor-1α and matrix metalloproteinase-2 in degenerative lumbar intervertebral disc[J];Journal of Southern Medical University;2010-05
4 FU Qiao;YU Le-hua;Department of Rehabilitation Medicine,Second Affiliated Hospital,Chongqing Medical University;Department of Rehabilitation Medicine,People's Hospital of Hainan Province;;Influence of L-aminoguanidine in inflammatory factor levels in degenerate intervertebral disc cells in vitro[J];Journal of Jilin University(Medicine Edition);2014-01
5 ZOU Zhiyuan,ZOU Guoyao,TANG Zhihong Department of Spine Surgery,Affiliated Hospital,Guilin Medical College,Guilin 541001;Expression of matrix metalloproteinase-2 in the degenerated lumbar intervertebral disc tissue[J];Journal of Zhengzhou University(Medical Sciences);2011-01
6 WANG Zhao-feng,WU Yu-chi,LUO Meng(The third Affiliated Hospital of Inner Mongolia Medical College,baotou 014010,China);The Expression And Significance Of Matrix Metalloproteinase-9 In Herniated Lumbar Intervertebral Disc[J];Journal of Diseases Monitor & Control;2009-04
7 YU Zhen-han1,2,JIANG Hong2,ZHOU Hong-hai1(1.Faculty of Traumatology and Orthopedics,Guangxi University of Chinese Medicine,Nanning,530001,China;2.Orthopedics Department,Suzhou Hospital of Traditional Chinese Medicine,Suzhou,215000,China);Research Progress on Resorption After Protrusion of Lumbar Vertebral Disc[J];Journal of Nanjing University of Traditional Chinese Medicine;2012-04
8 LI Yan,et al.(Ningxia Med.Coll.,Yinchuan 750004,China);Expression and significance of Matrix Metalloproteinase-3 in experimental lumbar degeneration disc[J];Ningxia Medical Journal;2007-03
9 Wang Gang;Mao RongJun;Wu Xunfu;Cao Zhenglin;Guang Honggang;Huo Zhiming;Department of Orthopaedic Surgery, Foshan Hospital of Traditional Chinese Medicine;;Comparison of nerve growth factor and p75 neurotrophinc receptor expression in patients with degenerative disc diseasXe and lumbar disc herniation[J];Lingnan Modern Clinics in Surgery;2013-06
10 WANG Hui;DING Wen-yuan;MA Lei;The 3rd Hospital of Hebei Medical University;;Prevalence of intervertebral vacuum phenomenon in degenerative lumbar scoliosis and its influencing factors[J];The Journal of Cervicodynia and Lumbodynia;2014-01
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved