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《Chinese Journal of Reparative and Reconstructive Surgery》 2015-01
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RESEARCH STATUS ON MOLECULAR BASIS OF INTERVERTEBRAL DISC DEGENERATION AND REPAIRING EFFECT OF PLATELET-RICH PLASMA

GUI Keke;YU Yonglin;Department of Orthopaedics,Jinshan Hospital,Fudan University;Department of Orthopaedics,Huashan Hospital,Fudan University;  
Objective To review the research status on the molecular basis of intervertebral disc degeneration and the repairing effect of platelet-rich plasma. Methods The related literature about the molecular basis of intervertebral disc degeneration and the repairing effect of platelet-rich plasma was reviewed,analyzed,and summarized. Results The molecular basis of intervertebral disc degeneration includes genetic influences,cell senescence,decreased matrix production,increased degradative enzyme production,proinflammatory cytokine expression,apoptosis,and neural ingrowth. Platelet-rich plasma can release a series of growth factors to promote intervertebral disc cells proliferation,differentiation,and extracellular matrix synthesis. It can also inhibit proinflammatory effect and apoptosis. Conclusion Although the prospect of using platelet-rich plasma to repair intervertebral disc degeneration is encouraging,further studies are still needed.
【Fund】: 上海市金山区科技创新基金项目(2012-3-05)~~
【CateGory Index】: R681.5
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【Co-citations】
Chinese Journal Full-text Database 10 Hits
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