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《CHINESE JOURNAL OF REPARATIVE AND RECONSTRUCTIVE SURGERY》 1998-01
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THE EFFECT OF BLOCKING INSULINLIKE GROWTH FACTOR1 (IGF1)RECEPTOR SYSTEM ON TENDON CELL PROLIFERATION

Xiang Zhou, Yang Zhiming, Zhang Caoliang et al. Department of Orthopedic surgery, First Univerisity Hospital, West China University of Medical Sciences, Chengdu, P.R.China 610041  
The purpose of this study was to find some solutions to the problem of tendon cell proliferation control. Under the condition of in vitro culture, several materials including IGF1 receptor antibody and mRNA antisense oligonucleotide were added to the culture medium to block the IGF1Receptor system. The effect of the material on the tendon cell proliferation was judged by cell count after incubation of 48 hours. The results showed that both IGF1 Receptor antibody (IGF1Rα) and IGF1 Receptor mRNA antisense oligonucleotide had negative effect on tendon cell proliferation (P0.01 and P0.05). These findings lead us to think that the above two materials could be used in the experiment of tendon adhesion preventing and living readymade tendon producing.
【Fund】: 国家自然科学基金
【CateGory Index】: R329-34,
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