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《CHINESE JOURNAL OF REPARATIVE AND RECONSTRUCTIVE SURGERY》 1998-01
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XENOGENEIC ANTIGENS AND IMMUNE RESPONSE IN PIG TO MAN XENOGRAFT

Li Tao, Li Youping, Yang Zhiming. Department of Orthopedic Surgery, First University Hospital, West China University of Medical Sciences, Chengdu, P.R.China 610041  
Limitation of donor source for allograft makes the research on xenograft progress. Pig is regarded as one of the ideal donor animals. the major obstacle in xenograft is hyperacute rejection, which is caused by complements after they are activated by xenogeneic antigens combined with natural antibodies. It has been confirmed that αGal is the major target antigen, whose expression is incharged by α1, 3 galactosyltronsferase (αGT). The approaches to overcome hyperacute rejection against αGal included: immunoadsorption of xenogeneic natural autibodies, lysis of antigen by enzyme and genetic manupilation to obtain animal lack of αGT. Besides αGal, there were other antigens binding to human serum antibody, such as gp65 and gp100, which was expressed on PAEC after induced by TNF, the Alike antigen. But their function was still unknown. It was debatable on the role of MHC in xenograft. Both direct and indirect pathway were involved in cellular response in xenograft.
【Fund】: 四川省重点科技项目
【CateGory Index】: R392.4,
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