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《Chinese Journal of New Drugs》 2014-04
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Effect of continuous oral cycloastragenol on the activity of cytochrome P450 enzymes in rats

WEI Bao-hong;YE Jing;XUE Bao-juan;SUN Gui-xia;YANG Xiao-yan;ZHANG Yu-jie;School of Chinese Materia Medica,Beijing University of Chinese Medicine;  
Objective: To determine the effect of cycloastragenol( CAG) on cytochrome P450 enzyme subtypes of rat liver microsomes. Methods: Rats were treated with CAG( 40 mg·kg- 1·d- 1) for 7 days to induce hepatic microsomal enzyme. Cocktail probe substrates were incubated with liver microsomes in vitro. Then,the metabolic elimination percentages of the five probe substrates metoprolol,aminophenylsulfone,chlorzoxazone,phenacetin and tolbutamide were determined by HPLC. The effect of CAG on the enzymatic activity of rat liver microsomal CYP450s was evaluated. Results: Compared with the control,CAG obviously activated CYP2E1,and remarkably inhibited CYP3A4. However,CAG did not significantly affect CYP2D6,CYP1A2 and CYP2C9. The IC50of CYP3A4 was 12. 13 μmol·L- 1,and inhibition type was competitive inhibition. Conclusion: CAG can remarkably inhibit CYP3A4 and activate CYP2E1.
【Fund】: 北京中医药大学研究生自主课题(5320100604286)
【CateGory Index】: R969.1
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Chinese Journal Full-text Database 4 Hits
1 Zhang Yanhui,Yu Chao,Guo Yanlei,Zhang Youjin,Li Wenjuan,Yang Zhu,Wang Yingxiong(Institute of Life Sciences,Chongqing Medical University,Chongqing,400016,China);Astragaloside Ⅳ exerts drug interactions via inhibiting CYP1A2 activity in rats[J];Journal of Third Military Medical University;2012-13
2 LIU Ying, JIAO Jian-jie, LOU Jian-shi Department of Pharmacology, Tianjin Medical University, Tianjin 300700, China;Progress of “Cocktail" probe substrates approaches[J];Chinese Journal of Clinical Pharmacology and Therapeutics;2006-11
3 SHAN Wenya,ZHANG Yufeng,ZHU Jieqiang,SHAO Qin,FAN Xiaohui(College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China);Inhibitory effects of astragaloside IV on cytochrome P450 enzyme of rat liver microsomes[J];China Journal of Chinese Materia Medica;2012-01
4 CAO Yan-ling1,2,LI Wen-lan1,WEI Ling-yu2,LIU Xiao-ya2,LI Zhi-hui2,HE Wei-guo3,ZHANG Yu-jie2*(1.Research Center for Life Science and Environmental Sciences,Haerbin University of Commerce,Haerbin 150028,China;2.School of Chinese Materia Medica, Beijing University of Traditional Chinese Medicine,Beijing 100102,China; 3.Beijing Medicass Biotechnologies Co.Ltd.,Beijing 100012,China);Anti-aging Function of Cycloastragenol in Aging Mice Induced by D-galactose[J];Chinese Journal of Experimental Traditional Medical Formulae;2012-19
Chinese Journal Full-text Database 10 Hits
1 LI Lan-fang1,TONG Ji-ming2,XIE Li-jun1,LI Guo-feng1,HAO Na1,ZHANG Qin-zeng1,WANG Wei1(1.Hebei Provincial Cent for Disease Control and Prevention,Shijiazhuang 050021,Hebei;2.Chengde Medical College,Chengde 067000,Hebei,China);Study on mutagenicity of fufang xiaojingtong capsules[J];Carcinogenesis,Teratogenesis & Mutagenesis;2010-01
2 DAN Fei-jun et al(Hubei Key Laboratory of Natural Products Research and Development,China Three Gorges University,Yichang,Hubei 443002);Antibacterial Action in vitro of Rodgersia aesculifolia Batal.[J];Journal of Anhui Agricultural Sciences;2009-10
3 LIU Xi-ling et al (Qingdao Agricultural University,Qingdao,Shandong 266109);Study on Antitumor Effect in vitro of Different Extractions by Water from Roots of Glehnia littoralis[J];Journal of Anhui Agricultural Sciences;2009-20
4 NI Yan-bo et al (Basic Medical School,Binzhou Medical University,Yantai,Shandong 264003);Effect of Grifola frondosa Polysaccharide on Cardiac Hemodynamics in Hypertensive Rats[J];Journal of Anhui Agricultural Sciences;2009-25
5 DONG Hua-ze et al(Department of Chemistry and Chemical Engineering,Hefei Teachers College,Hefei,Anhui 230061);Effect of Foeniculum vulgare Mill on the Immunological Functions in Mice[J];Journal of Anhui Agricultural Sciences;2009-27
6 CHEN Peng et al (Ocean School of Yantai University,Yantai,Shandong 264005);Hepatoprotective Effects of Phenolic Acid from Salvia chinensis Benth. on Carbon Tetrachloride-Induced Acute Liver Injury in Mice[J];Journal of Anhui Agricultural Sciences;2010-09
7 QI Hong-li et al (Department of Fishery Science of Tianjin Agricultural University,Key Laboratory of Aquatic Ecology and Aquaculture of Tianjin,Tianjin 300384);Effect of Water Decoction of Rhubarb on the Isolated Intestinal Movement of Ophicephalus argus[J];Journal of Anhui Agricultural Sciences;2010-10
8 ZHANG Li-yuan et al (Anatomy Staff Room of Guangdong Medical College, Zhanjiang, Guangdong 524023);Study on Anti-tumor Activity of Ginseng Fiber Particles in vitro and in vivo[J];Journal of Anhui Agricultural Sciences;2010-11
9 WANG Xiang-fei et al (Key Laboratory of Xinjiang Endemic Phytomedicine Resources,Ministry of Education/Pharmacy College,Shihezi University,Shihezi,Xinjiang 832002);Primary Exploration on Antibacterial Active Part of Extract from Orostachys spinosa (L.) C.A. Mey[J];Journal of Anhui Agricultural Sciences;2010-25
10 QIAO Qian et al(College of Fisheries,Ocean University of China,Qiangdao,Shanghai 266001);Isolation and Identification of Pathogenic Pseudoalteromonas sp. and Antibiotic Sensitivity Research[J];Journal of Anhui Agricultural Sciences;2010-26
China Proceedings of conference Full-text Database 10 Hits
1 ;Effects of Marine Collagen Peptide on serum SOD、MDA、GSH、NO of type two diabetes rats[A];[C];2008
2 Liu GuiQin1,Zhu CuiFeng2,41,Li YanFei 3,Guo SongChao31,Li Yong4,et al.(1. Shenzhen City FuTian districtation Chinese Traditional Medical Hospital;Shenzhen 518036,China);Effects of Marine Collagen Peptide on serum SOD、MDA、GSH、NO of type two diabetes rats[A];[C];2008
3 Zhang Huiyun,Wei Sheng,Xue Ling,Li Honghua (Shandong University of Traditional Chinese Medicine,Key Laboratory of Traditional Chinese Medicine Classics Theory,Jinan 250355,China);Effect of Jingqianshu Granule(Chinsese Patent drug) on the Expression of 5HT_(3B) Receptor in Rat Hippocampal[A];[C];2010
4 ZHANG Jin-lin,NI Mei-xin,LIU Jin-bing,SHEN Kang,ZHANG Yi-xin Affiliated Tumor Hospital of Nantong University,Nantong 226361,China;Influence of Bu Kang Ling on chemotherapy effects and immune function in mice bearing Lewis lung cancer[A];[C];2010
5 Zhao xiaofeng, Huang en, Zhang wei(No.324 Hospital of the PLA, Chongqing, 400020);Allergic and haemolytic test for Pazufloxacin mesilate Sodium Chloride Injection[A];[C];2006
6 ;肝康颗粒对小鼠免疫性肝损伤的保护作用[A];[C];2006
7 TongLI. Xiao-Changhong. Chen-yuyao. (Southern Medical University GuangZhou 510515);Inhibition of Celastrus extract on the model in type Ⅱ collagen-induced arthritis in rat[A];[C];2006
8 WANG-Gang~1 LIU-Bin~1 QI-Bin~2 CHEN-Huaqiong~1 DU Biao~3 (1.Children's Hospital,Chongqing University of Medical Sciences,Chongqing 400014,China, 2.Shiyan Maternal and Child health Hospital,Shiyan 442001; 3 Dept.of pharmacy,Hospital Chong qing sanxia chong qing 404000);Experiment study on antihepatic fibrosis effect of chai-hu and ge-gen in wistar mice[A];[C];2007
9 MAHEMUTI Maierdan1,2 HUJIA Gulixian 2 AIKEMU Mehesumu 1 (1.Affiliated Tumor Hospital,2.Department of pharmaceutics,College of Pharmacy,Xinjiang Medical University,Urumqi 830011,China);Study on the antidiarrhea effect of Elaeagnus angustifolia L.granule formulation[A];[C];2008
10 LIU Gao-feng ZHEN Li-mian(Department of Pharmacy,the Second Affiliated Hospital of Harbin Medical University,Key Laboratory of University in Heilongjiang Province,Harbin 150086,China);Review on the effects of Traditional Chinese Medicines on cytochrome P450 system by Cocktail probe drugs[A];[C];2008
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 YANG Xiu wei, ZHAO Jing, CUI Jing rong △, GUO Wei (State Key Laboratory of Natural & Biomimetic Drugs, Peking University School of Pharmaceutical Sciences, Beijing 100083, China);Studies on the biotransformation of escin Ia by human intestinal bacteria and the anti-tumor activities of desacylescin I[J];Journal of Peking University(Health Sciences);2004-01
2 MAO Yu, YU Hong-shan, JIN Feng-xie(School of Biological & Foodstuff Engineering, Dalian Institute of Light Industry, Dalian 116034,China);Screening of microbal strains produced by astrogaloside glycosidase and its optimal condition for enzyme hydrolysis[J];Journal of Dalian Institute of Light Industry;2005-01
3 XIAO Li-li~1,WU Xiao-qian~2,YU Hong-shan~1(1.School of Biological & Foodstuff Engineering,Dalian Institute of Light Industry,Dalian 116034,China;2.Dalian Zhen-ao Group Company,Dalian 116620,China);Separation and purification of Astragaloside product from biotransformation[J];Journal of Dalian Institute of Light Industry;2006-02
4 ZHONG Ling1,QIU Yan-chuan2,SHANG Jing-chuan1(1Department of Drug Analysis,School of Pharmaceutical Science,Chongqing Medical University,Chongqing 400016;2Department of Pharmaceutics,Chongqing Medical and Pharmaceutical College,Chongqing 400030,China);Determination of droxidopa in human plasma and pharmacokinetic features[J];Acta Academiae Medicinae Militaris Tertiae;2009-11
5 LI Xue-Ning, LI Zhi-Shan, ZHU Jun-Ren(Department of Clinical Pharmacology, Zhong Shan Hospital, Shanghai Medical University,Shanghai,200032);THE INTERACTIONS BETWEEN GRAPEFRUIT JUICE AND DRUGS[J];THE CHINESE JOURNAL OF CLINICAL PHARMACOLOGY;1999-05
6 QIU Bai-cheng,LIU Qing-feng(Department of Plastic Surgery,the First Affiliated of Hospital Guangxi Medical University,Nanning 530001,China);The Assessment of the D-galactose Rat Aging Model[J];Guangxi Medical Journal;2009-07
7 Hu Jinping, Yan Shulian, Tang Jingcheng, Zhang Jinnan Department of Chemical Pharmacology, Capital University of Medical Sciences;Simultaneous Evaluation of Effect of Rhizoma Curcumae Longae on Hepatic CYP_(450) by Cocktail Probe Drugs[J];Journal of Capital University of Medical Sciences;2004-04
8 CHEN Ning,ZHANG Qi,DU Yu,CHEN Guo-guang,ZHU Ling-ling(College of Life Science and Pharmaceutical Engineering,Nanjing University of Technology,Nanjing 210009,China);Pharmacokinetics and tissue distribution of astragaloside Ⅳ in rats[J];Chinese Journal of Bioprocess Engineering;2006-03
9 LIU Keming, WANG Chunhua, LI Guoxing, HE Ning, et al.Tianjin Centers for Disease Control and Prevention, Tianjin 300011,China;A comparison study between D-galactose treated mice and natural aging mice[J];Journal of Hygiene Research;2007-06
10 SHI Hai-lian~(1,2),LIU Yan~(1,2),MA Chun-lai~(1,2),HU Zhi-bi~(1,2),WU Da-zheng~(1,2,3) (1.Institute of Chinese Materia Medica,Shanghai University of Traditional Chinese Medicine,SHANGHAI 201203,China;2.Shanghai Key Laboratory of Complex Prescription,SHANGHAI 201203,China;3.E-Institute of Traditional Chinese Medicine Internal Medicine,Shanghai Municipal Education Commission, SHANGHAI 201203,China);Effect of astragaloside Ⅳ on relaxation and molecule mechanism in isolated rat aortic rings from hypertensive rats[J];Chinese Journal of New Drugs and Clinical Remedies;2009-12
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