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《Chinese Journal of New Drugs》 2015-14
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Research progress in application of functional film coatings in the oral multiple-unit pulsatile delivery system

YANG Jin-lan;SHAN Li;WANG Yu-li;GAO Chun-sheng;Pharmaceutical College of Henan University;The Institute of Pharmacology and Toxicology,Chinese Academy of Military Medical Sciences;  
Pulsatile delivery system,also referred as time-controlled release system,can release the active ingredient timely according to the time attack regularity. Compared to the single-unit dosage forms,multiple-unit system has a good regulatory of the release and has become the focus in the pulsatile delivery system. At present,the release curve feature of the oral multiple-unit pulsatile delivery system is mostly achieved by the functional film coatings. Therefore,the application and the categories of the functional film coatings were reviewed. The effect of the coating formulation on the drug release and the corresponding mechanism of the drug release were also discussed in this article.
【Fund】: 国家“重大新药创制”科技重大专项(2012ZX09301003-001)
【CateGory Index】: R943
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