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《Chinese Pediatrics of Integrated Traditional and Western Medicine》 2017-04
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Effect of montelukast combined with vitamin C in the treatment of children with allergic purpura

DING Yunfeng;LI Zhihui;DUAN Cuirong;XUN Mai;WU Tianhui;ZHANG Yi;Department of Nephrotic Rheumatology,Hunan Children's Hospital;  
Objective To investigate the clinical efficacy of montelukast combined with vitamin C in the treatment of allergic purpura in children.Methods From November 2014 to January 2010,86 children with Henoch-Schonlein purpura were hospitalized and treated in the Department of Nephrotic Rheumatology,Hunan Children's Hospital,and they were randomly divided into control group(43 cases)and observation group(43 cases).The control group was treated with montelukast orally taken.The observation group was treated with vitamin C in addition to monteleukast,and the treatment lasted for 7 days.The levels of plasma cytokine(interleukin 6,interleukin 8,tumor necrosis factorα)and adverse effects were compared between the two groups after treatment.Results The total effective rate was 95.35%(41/43)in the observation group,which was significantly higher than that in the control group(81.40%,35/43),and the difference was statistically significant(P0.05).After treatment,the level of interleukin 6,interleukin 8 and tumor necrosis factorαwas significantly lower in the observation group than in the control group(P0.05).The incidence of adverse events in the observation group was 2.33%(1/43),which was significantly lower than that of the control group(18.60%,8/43)(P0.05).Conclusion The combination therapy of montelukast with vitamin C for children with Henoch-Schonlein purpura is effective and safe,with lower adverse reaction incidence.It is worthy of clinical application.
【Key Words】: Allergic purpura Montelukast Vitamin C Combination therapy Children
【CateGory Index】: R725.5
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