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《Zhejiang Journal of Preventive Medicine》 2003-01
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A Meta-analysis Study on Metabolizing Enzyme Polymorphisms of Colorectal Cancer

WT6BX]Jiang Qinting, Chen Kun. Department of Epidemiology, Zhejiang University School of Medicine, Yan an Road 353#, Hangzhou, Zhejiang 310006, P. R. China[KH2D]  
Objective To evaluate the relationship between genetic polymorphisms of metabolizing enzyme and colorectal cancer. Methods The results of 42 epidemiological studies from 1990 to 2001 were analyzed by means of Meta analysis. Mantel Haenszel fixed effects model, Dersimonian Lair random effects model and ReviewManager4 1 statistical program were applied in processing data. Results The pooled OR values of GSTM1 deletion, GSTT1 deletion, GSTP1 lle105Val, NAT1*10, NAT2 rapid acetylator phenotypegenotype, NAT2 rapid acetylator phenotype, NAT2 rapid acetylator genotype, CYP1A1 Lle462Val, CYP1A1 MspI*C, MTHFR C677T and MTR A2759G were 1 06, 1 42, 1 09, 1 25, 1 08, 1 15, 1 05, 1 26, 1 30, 0 83 and 0 60 respectively. Conclusions Genetic polymorphisms of colorectal cancer are significantly associated with the GSTT1 deletion, NAT2-rapid acetylator phenotypegenotype and NAT2-rapid acetylator phenotype. [
【Fund】: 国家自然科学基金项目 项目批准号 :30 170 82 8
【CateGory Index】: R735.34
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