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《Zhejiang Journal of Preventive Medicine》 2004-01
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The Expression and Clinical Significance of PCNA and C-erbB-2 in Breast Cancer Tissue

WANG Liang, DENG Yong-chuan, LIN Min, et al. ( The Second Affiliated Hospital of Zhejiang University School of Medicine , Hangzhou , Zhejiang, 310009, China)  
Objective To determine the relationship between the axillary nodes metastases and the expression of PCNA and C-erbB-2 in breast cancer tissue. Methods The expression of PCNA and C-erbB-2 in breast cancer tissue sample were detected by immunohistochemical method in 44 patients. Results Among 44 patients, there were 39 cases with over-expression of PCNA and 29 cases with over-expression of C-erbB-2. The over-expression of PCNA was significantly correlated with axillary lymph nodes metastases (P 0.05, RR = 2.6), and the over-expression of C-erbB-2 was also significantly associated with axillary lymph metastases (P0.05, RR = 6.l) . Conclusions Both PCNA and C-erbB-2 are over-expressed in breast cancer tissue, and the expression of PCNA and C-erbB-2 are significantly associated with the axillary lymph nodes metastases.
【CateGory Index】: R737.9
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