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《Zhejiang Journal of Preventive Medicine》 2007-01
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Screening of Phenotypic Features for Grouping during Linkage Analysis in Children with Familial Febrile Seizures

WANG Xiu-min, XU Mei-chun, SHUI Quan-xiang.(The Affiliated Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310003,China.)  
Objective To explore the phenotypic features that can reduce genetic heterogeneity of children with febrile seizures (FS) as to increase the effectiveness of linkage analysis. Methods The study involved 127 children whose father or mother ever suffered from FS in childhood as the case group, and 152 children whose parents didn't as the control group. The unmatched case-control design was applied to study the association between phenotypic features and parental history of FS. Results The sex ratio(boys:girls) of children with FS was 1.46:1. Relationship between recurrent FS (recurrent number ≥2) and parental history of FS had statistical significance. Significant difference could not be found in recurrent risk between the case group and control group. After adjustment for age and sex, age over 36 months when the first attack occurred was an independent risk factor of FS recurrence. The appearance of afebrile seizures after FS was also independently associated with FS recurrence, and its risk ratio was higher than familial FS history. Conclusions FS recurrence, afebrile seizures and age over 36 months when the first attack occurred can be used as screening standard in grouping during the linkage analysis, which will be of great significance to reduce the genetic heterogeneity.
【Fund】: 浙江省卫生厅科研基金资助项目(2003B101)
【CateGory Index】: R720.597
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