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《Preventive Medicine》 2018-01
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Association between human papillomavirus infection and adverse pregnancy outcome

ZHOU Jing;OU Rong-ying;ZHOU Mei-qian;CHEN Xiang-juan;BAO Ying;ZHANG Wen-miao;Department of Obstetrics,the First Affiliated Hospital of Wenzhou Medical University;  
Objective To investigate the infection rate of human papillomavirus(HPV) among pregnant women, and to explore the effect of HPV infection on adverse pregnancy outcome. Methods A total of 1 679 pregnant women in hospital were collected for the research. The flow-through hybridization and genechip(Hybri Max) method was used to detect the infection of HPV. Univariate analysis was used to analyze the factors affecting HPV infection in pregnant women. The binary logistic analysis was used to analyze risk factors affecting adverse pregnancy outcome. Results HPV infection rate was 31.39%(527/1 679),including 14.23%(239/1 679) of HR-HPV,15.54%(261/1 679) of LR-HPV and 1.61%(27/1 679) of mixed of HR-HPV and LR-HPV. Univariate analysis showed that there was significant difference in initial sex age, education level and smoking history between infection group and non-infection group,with statistical difference(P0.05). The incidence rate of adverse pregnancy outcomes in infection group(31.50%) was significant higher than that of non-infection group(9.81%), with statistical difference(P0.01). The incidence rate of premature rupture of fetal membranes,newborn respiratory papillomatosis and other adverse pregnancy outcomes among HR-HPV group, LR-HPV group and mixed group had no significant difference(P0.05). Binary logistic regression analysis showed HR-HPV infection(OR=4.194,95%CI:3.099-5.675),LR-HPV infection(OR=1.771, 95% CI: 1.288-2.434) and mixed type infection(OR= 3.350, 95% CI: 1.630-7.735) were the risk factors affecting adverse pregnancy outcome(P0.01),however,age and times of gestation had no statistical significance in the binary logistic analysis(P0.05). Conclusion HPV infection was the risk factors for adverse pregnancy outcome,which indicated that screening work in pre-pregnancy and pregnancy, and persisting in early prevention, early detection and early treatment could reduce the incidence rate of adverse pregnancy outcome.
【Fund】: 国家自然科学基金(81373075)
【CateGory Index】: R714.2;R737.33
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