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《Preventive Medicine》 2018-01
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Correlations of serum CEA and CA19-9 levels with clinical staging of colorectal cancer

ZHANG Li-hua;GU Si-meng;YE Ding;ZHANG Yu-ping;LI Zhen-jun;YING Xiao-jiang;Department of Anorectal Surgery of the Shaoxing People's Hospital;  
Objective To evaluate the value of serum CEA and CA19-9 concentration for clinical staging of colorectal cancer.Methods A total of 350 patients who underwent the surgical treatments for colorectal cancer between February 2015 to January2017 were enrolled. The serum CEA and CA19-9 were detected by chemoluminescence method. Results The positive rate of CEA of patients in stage Ⅰ to Ⅳ was 25.00%, 36.69%, 50.78% and 66.67%, respectively. The positive rate of CA19-9 of patients in stageⅠto Ⅳ was 2.94%,10.07%,17.97% and 53.33%,respectively. The positive rates of CEA and CA19-9 were gradually increased with the stage developing(P0.05). Results from multivariate logistic regression analysis showed that the positive levels of CEA and CA19-9 were risk factors in the TNM staging of colorectal cancer. The ORs and 95%CI were 1.790(1.163-2.755) and 3.476(1.790-6.749),respectively. Conclusion The positive serum concentrations of CEA and CA19-9 showed significant associations with TNM staging. Preoperative serum concentrations of CEA and CA 19-9 could be auxiliary diagnostic indicators to assess the condition of colorectal cancer.
【Fund】: 国家重点基础研究发展计划(973计划)项目(2015CB554003);; 浙江省医药卫生平台计划课题(2016ZDB013);; 浙江省公益技术应用研究项目(2016C33225)
【CateGory Index】: R735.34
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