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《Preventive Medicine》 2018-10
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Efficacy and influencing factors of treatment for multidrug-resistant tuberculosis in Lishui

GUO Jing;LIU Zhong-da;ZHANG Zun-jing;YE Chun-fu;XIE Xiao-tao;ZHOU Guang-nao;ZHANG Xiao-wei;Lishui Hospital of Traditional Chinese Medicine;  
Objective To understand the efficacy of standardized treatment for multidrug-resistant tuberculosis(MDR-TB) and the influencing factors for the treatment outcomes in Lishui. Methods From April 2010 to December 2016,MDR-TB patients who were confirmed and agreed to be treated with standardized regimen in Lishui were observed and recorded. Logistic regression model was used to analyze the influencing factors for the treatment outcomes. Results A total of 68 MDR-TB patients were enrolled in the study,of which 28 cases were cured(41.18%),9 cases completed the treatment course(13.23%),12 cases failed(17.65%),12 cases were interrupted or lost(17.65%) and 7 cases(10.29%) died. Adverse drug reaction was observed in 23 cases and treatment was terminated or changed permanently in 18(78.26%) of these cases. The most common adverse reaction was gastrointestinal reactions. The logistic regression analysis showed that the risk factors for adverse outcome(failure,death and interruption or loss) in MDR-TB patients were lesion without improvement in radiography during treatment(OR=34.930, 95% CI: 4.669-261.324), positive sputum culture for tuberculosis after 6-month treatment( OR=15.846, 95% CI: 2.004-125.321) and termination of treatment due to adverse reaction(OR=10.762, 95% CI: 1.134-102.124). Conclusion The treatment success rate of MDR-TB is low and this is associated with no improvement in radiography,no negative sputum culture and too many adverse reactions during treatment.
【Fund】: 浙江省科技计划项目(2017C33198);; 丽水市高层次人才项目(2015RC34)
【CateGory Index】: R521
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