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《Occupation and Health》 2012-04
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Cbfα1 gene expression in the dentary germ of rat offspring due to lead exposure in early gestation

YU Ai-min,LIU Li,LUO Nan-hong,LIU Zhi-yong Jiangxi Institute for Occupational Disease Prevention,Nanchang,330006,China  
[Objective]To investigate the Cbfal gene expression in the dentary germ of rat offspring due to lead exposure in early gestation.[Methods]A total of 30 pregnant SD rats were divided into 3 groups randomly(10 for each group): control group,low level lead group(60 mg/kg) and high level lead group(240 mg/kg).The 3 groups from the gestation to the weaning of rat offspring were given either deionized water or lead acetate.After birth 2 d,4 d,8 d,10 d,the rat offspring were killed by pulling the neck.and their bilateral mandibular under first molar with surrounding alveolar bone were taken out,then the tissues were fixed with 4% paraformaldehyde over night,dehydrated,embedded in paraffin and serially sectioned at 5 μm.Immunohistochemical assay(HE staining + Power VisionTM)was adopted to determine the dentary germ development.[Results]Pathological histology analysis showed adamantine layer thinningz even disappearance with the lead exposure in test group.Immunohistochemical assay showed the Cbfα1 gene expression was suffered influence.[Conclusion]The Cbfal gene expression is obviously inhibited in the dentary germ of rat offspring due to lead exposure in early gestation.
【Fund】: 江西省卫生厅科技项目(项目编号:20093146)
【CateGory Index】: R714.2
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 PAN Ke-qing, YANG Pi-shan, LI Shu. (Department of Periodontology, School of Stomatology, Shandong University. Jinan 250012, Shandong Province,China);Expression of mineral-associated factors in the mineral stage tooth germ of mice[J];Shanghai Journal of Stomatology;2006-04
2 GENG Hua-ou*,ZHANG Jin-cai,ZHOU Lei,CAI Hai-yan,WANG Jing-bin.*College of Stomatology,Wuhan University,Wuhan 524023,China;The effect of lead exposure in utero on the teeth eruption and enamel development of rat offspring[J];Chinese Journal of Industrial Hygiene and Occupational Diseases;2005-01
【Co-citations】
Chinese Journal Full-text Database 2 Hits
1 LIN Ri-yang1,WU Feng1,HE Li-qun1,2,3(1Shanghai University of TCM,Shanghai 201203,China;2Nephrology Department,Shuguang Hospital Affiliated to Shanghai University of TCM,Key Laboratory of Liver and Kidney Disease,Ministry of Education,TCM Internal Medicine E-institute of Shanghai High School,Shanghai 200021,China;3Key Clinical Laboratory of Shanghai,Shanghai 200021,China);Effects of mesangial cells on expressions of collagen Ⅰ and cbfα1 in osteoblasts base on the foundation of tonifying kidney herbs[J];China Journal of Traditional Chinese Medicine and Pharmacy;2012-06
2 Liu Shu-fa,Wang Xiao-wei,Wang Li-feng,Huo Dong-ying,Gu Xiao-ming First Department of Orthognathic Surgery,the Second Affiliated Hospital of Jiamusi University,Jiamusi 154007,Heilongjiang Province,China;Effect of caffeine on rat tooth germ development[J];Chinese Journal of Tissue Engineering Research;2012-46
【Secondary Citations】
Chinese Journal Full-text Database 6 Hits
1 LI Shu,PAN Ke-qing,GE Shao-hua,XIE Rui-yue,DUAN Xue-jing,YANG Pi-shan. (Department of Periodontology,School of Stomatology,Shandong University. Jinan 250012,Shandong Province,China)[;Histological location of DMP1,OPN and BSP in cementum formation of mouse[J];Shanghai Journal of Stomatology;2005-01
2 Nie Xin, Jin Yan, Zhang Yongjie, et al. Department of Oral Histology and Pathology, College of Stomatology, Fourth Military Medical University, Xi'an 710032,China;The effects of dentin non-collagen proteins and transforming growth factor-β1 on the proliferation, ALP activity and mineralization of human dental pulp cells in vitro[J];Journal of Practical Stomatology;2004-02
3 GUO Peng, WU Bu-ling, TIAN Yu, et al (College of Stomatology,The Fourth Military Medical University, Xi′an 710032, China);Immunolocalization of ameloblastin in developing mouse tooth germ[J];Chinese Journal of Conservative Dentistry;2003-03
4 Shen Xiaoming, Yan Chonghuai, Wu Shengmei, et al. Shanghai Second Medical University Center for Childhood Lead Poisoning Research, Shanghai 200092;Prenatal low level lead exposure and infant development in the first year: a prospective study in Shanghai, China[J];Chinexe Journal of Pediatrics;1997-04
5 OUYANG Wei , LI Yujing, LIU Zuomin, et al Research Institute of Stomatology, Beijing Stomatological Hospital, Beijing 100050,China;Effect caused by uptake of different levels of calcium to enamel fluorosis in rats[J];CHINESE JOURNAL OF STOMATOLOGY;2000-01
6 YU Qing, XIAO Ming zhen, WU Bu ling, ZHU Qing lin, GUO Ting, LI Feng Department of Operative Dentistry and Endodontics, College of Stomatology, The Fourth Military Medical University, Xi′an 710032,China;Cbfa1 induces the expression of the mineral-related proteins in human dental papilla cells[J];Chinese Journal of Stomatology;2003-04
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