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《Occupation and Health》 2012-04
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Cbfα1 gene expression in the dentary germ of rat offspring due to lead exposure in early gestation

YU Ai-min,LIU Li,LUO Nan-hong,LIU Zhi-yong Jiangxi Institute for Occupational Disease Prevention,Nanchang,330006,China  
[Objective]To investigate the Cbfal gene expression in the dentary germ of rat offspring due to lead exposure in early gestation.[Methods]A total of 30 pregnant SD rats were divided into 3 groups randomly(10 for each group): control group,low level lead group(60 mg/kg) and high level lead group(240 mg/kg).The 3 groups from the gestation to the weaning of rat offspring were given either deionized water or lead acetate.After birth 2 d,4 d,8 d,10 d,the rat offspring were killed by pulling the neck.and their bilateral mandibular under first molar with surrounding alveolar bone were taken out,then the tissues were fixed with 4% paraformaldehyde over night,dehydrated,embedded in paraffin and serially sectioned at 5 μm.Immunohistochemical assay(HE staining + Power VisionTM)was adopted to determine the dentary germ development.[Results]Pathological histology analysis showed adamantine layer thinningz even disappearance with the lead exposure in test group.Immunohistochemical assay showed the Cbfα1 gene expression was suffered influence.[Conclusion]The Cbfal gene expression is obviously inhibited in the dentary germ of rat offspring due to lead exposure in early gestation.
【Fund】: 江西省卫生厅科技项目(项目编号:20093146)
【CateGory Index】: R714.2
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