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《Occupation and Health》 2012-04
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Clinical observation on decline of hepatitis B surface antibody titer in maintenance hemodialysis patients

ZHANG Yan-zhi,SU Wei,SHANG You-quan,ZHAO Xue-yi Department of Hemodialysis,Baoji Central Hospital,Shaanxi,721008,China  
[Objective]To observe the decline changes of hepatitis B surface antibody titer in maintenance hemodialysis patients.[Methods]88 maintenance hemodialysis patients whose anti-HBs titers were higher than 10mIU/ml were divided into two groups.Group A(45 cases) have had the protective antibody before hemodialysis,and group B(43 cases) have had the protective antibody after hepatitis B vaccination.There were two methods of vaccination.①long-term intramuscular injection: 25 patients received 4 does by intramuscular injection at 0,1,3 and 6 months,20 μg per dose.② Low-dose multiple intracutaneous injection: 18 patients were given 6 does by intracutaneous injection every two weeks,5 μg per dose.The decline of hepatitis B surface antibody titer was observed in 6 months.[Results]The antibody titer of group A had descended by 19.66%,that of group B had descended by 57.84%,and the difference between two groups was significant(P0.01).The antibody titer of first vaccination method had descended by 45.41%,that of second vaccination method had descended by 62.78%,and the difference was significant(P0.05).[Conclusion]The decline of antibody titer of patients have had the protective antibody before hemodialysis is slower than that of patients inoculated hepatitis B vaccination after hemodialysis,and its immune protection lasts for a long time.The antibody titer decline of long-term intramuscular injection is slower than that of low-dose multiple intracutaneous injection.The sample size of this study is small,so it may need further study by enlarging sample size.
【CateGory Index】: R459.5
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 HUANG Song-min,CHEN Xiao-lei;Hepatitis B virus infection in hemodialysis[J];Chinese Journal of Practical Internal Medicine;2008-01
2 SU Wei,ZHANG Huan-qiao,SHANG You-quan,ZHANG Yan-zhi. Department of Nephrology,Baoji Central Hospital,Baoji 721008,China;Therapeutic effect of two inoculation methods for hepatitis B vaccination in hemodialysis patients[J];Chinese Journal of Blood Purification;2010-05
【Co-citations】
Chinese Journal Full-text Database 7 Hits
1 YAN Shi-peng,PAN Hui-qiong,LI Lu-chi,LI Xiao-ling,LI Man-ling,ZHOU Min(The First Hospital of Changsha,Changsha 410005,China);Risk factors for hepatitis C virus infection in hemodialysis patients at a hospital in Changsha[J];Chinese Journal of Infection Control;2012-02
2 Li Ji-xia,Luo Nan-ping,Gong Yan-wen,et al. Department of Laboratory Diagnosis,Jinan Military General Hospital,Jinan(250031),China;Investigation on HIV,TP,HBV,HCV Infection in Patients Accepting Maintenance Hemodialysis[J];Journal of Radioimmunology;2012-04
3 ;老年肾功能衰竭血液透析患者的护理体会[J];Seek Medical and Ask the Medicine;2012-04
4 SHANG You-quan,ZHANG Yan-zhi,SU Wei,et al.Department of Nephrology,The Central Hospital of Baoji,Baoji Shaanxi 721008,China.;Observation and analysis of the change of hepatitis B surface antibody levels in maintenance hemodialysis patients[J];Journal of Clinical and Experimental Medicine;2012-03
5 CAI Yuelian (Wuzhou Workers Hospital,Wuzhou 543000,China);Infection Control in Reuse of Blood Dialyzer[J];Clinical Medicine & Engineering;2010-04
6 SU Wei,ZHANG Huan-qiao,SHANG You-quan,ZHANG Yan-zhi. Department of Nephrology,Baoji Central Hospital,Baoji 721008,China;Therapeutic effect of two inoculation methods for hepatitis B vaccination in hemodialysis patients[J];Chinese Journal of Blood Purification;2010-05
7 WONG Hong-leng,PENG Hong-quan,LIN Wan-ping,YAN Ya-yi.Hemodialysis center,Kiang Wu Hospital,Macau;Clinical investigation and analysis in maintenance hemodialysis patients with HBV and HCV infection[J];Chinese Journal of Blood Purification;2012-03
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 HUANG Song-min,CHEN Xiao-lei;Hepatitis B virus infection in hemodialysis[J];Chinese Journal of Practical Internal Medicine;2008-01
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