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《Occupation and Health》 2012-04
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Clinical observation on decline of hepatitis B surface antibody titer in maintenance hemodialysis patients

ZHANG Yan-zhi,SU Wei,SHANG You-quan,ZHAO Xue-yi Department of Hemodialysis,Baoji Central Hospital,Shaanxi,721008,China  
[Objective]To observe the decline changes of hepatitis B surface antibody titer in maintenance hemodialysis patients.[Methods]88 maintenance hemodialysis patients whose anti-HBs titers were higher than 10mIU/ml were divided into two groups.Group A(45 cases) have had the protective antibody before hemodialysis,and group B(43 cases) have had the protective antibody after hepatitis B vaccination.There were two methods of vaccination.①long-term intramuscular injection: 25 patients received 4 does by intramuscular injection at 0,1,3 and 6 months,20 μg per dose.② Low-dose multiple intracutaneous injection: 18 patients were given 6 does by intracutaneous injection every two weeks,5 μg per dose.The decline of hepatitis B surface antibody titer was observed in 6 months.[Results]The antibody titer of group A had descended by 19.66%,that of group B had descended by 57.84%,and the difference between two groups was significant(P0.01).The antibody titer of first vaccination method had descended by 45.41%,that of second vaccination method had descended by 62.78%,and the difference was significant(P0.05).[Conclusion]The decline of antibody titer of patients have had the protective antibody before hemodialysis is slower than that of patients inoculated hepatitis B vaccination after hemodialysis,and its immune protection lasts for a long time.The antibody titer decline of long-term intramuscular injection is slower than that of low-dose multiple intracutaneous injection.The sample size of this study is small,so it may need further study by enlarging sample size.
【CateGory Index】: R459.5
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