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《Occupation and Health》 2012-04
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Clinical observation of lamivudine in the treatment of tuberculosis combined with chronic hepatitis B virus infection

ZHAO Xiao-ling,XU Lin-sheng Department of Gastroenterology,Anqing Hospital of PLA Navy,Anhui,246003,China  
[Objective]To observe the efficacy of lamivedine on control of liver damage and inhibition of hepatitis B virus(HBV)replication in patients with tuberculosis combined with chronic HBV infection.[Methods]The patients were randomly divided into two groups.The control group was given 2HRZE/4HR+vitamin C+ liver-aid tablets,and the study group was given 2HRZE/4HR+ lamivedine+ vitamin C+ liver-aid tablets.The changes of liver function and HBV-DNA levels before and after treatment were evaluated.[Results]During the course of treatment,the incidence of liver damage in the study group was 12.8%,while that in the control group was 48.7%(P0.05).At the end of treatment,the HBV-DNA level in the study group was(4.1±0.2) log copies/ml,and that in the control group was(8.7±0.3) log copies/ml(P0.05).During the period of follow-up of drug withdrawal,there was no significant difference in the incidence of liver damage and HBV-DNA level between the two groups(P0.05).[Conclusion]Lamivedine can effectively inhibit the HBV replication and reduce the incidence of liver damage,which may be beneficial to the anti-tuberculosis therapy for the patients with tuberculosis combined with chronic HBV infection.
【CateGory Index】: R512.62
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