Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Occupation and Health》 2012-04
Add to Favorite Get Latest Update

Clinical observation of lamivudine in the treatment of tuberculosis combined with chronic hepatitis B virus infection

ZHAO Xiao-ling,XU Lin-sheng Department of Gastroenterology,Anqing Hospital of PLA Navy,Anhui,246003,China  
[Objective]To observe the efficacy of lamivedine on control of liver damage and inhibition of hepatitis B virus(HBV)replication in patients with tuberculosis combined with chronic HBV infection.[Methods]The patients were randomly divided into two groups.The control group was given 2HRZE/4HR+vitamin C+ liver-aid tablets,and the study group was given 2HRZE/4HR+ lamivedine+ vitamin C+ liver-aid tablets.The changes of liver function and HBV-DNA levels before and after treatment were evaluated.[Results]During the course of treatment,the incidence of liver damage in the study group was 12.8%,while that in the control group was 48.7%(P0.05).At the end of treatment,the HBV-DNA level in the study group was(4.1±0.2) log copies/ml,and that in the control group was(8.7±0.3) log copies/ml(P0.05).During the period of follow-up of drug withdrawal,there was no significant difference in the incidence of liver damage and HBV-DNA level between the two groups(P0.05).[Conclusion]Lamivedine can effectively inhibit the HBV replication and reduce the incidence of liver damage,which may be beneficial to the anti-tuberculosis therapy for the patients with tuberculosis combined with chronic HBV infection.
【CateGory Index】: R512.62
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 1 Hits
1 ;2004年拉米夫定临床应用专家共识[J];Chinese Journal of Infectious Diseases;2004-04
Chinese Journal Full-text Database 10 Hits
1 The Fourth People's Hospital of Feidong County, Feidong 231600, Anhui XU Zu-jun;The Treatment of Chronic Hepatitis B[J];Journal of Anhui Health Vocational & Technical College;2007-06
2 YANG Hui-yuan,SONG Yu-ling,XU Jian-ming(Department of Gastroenterology,The First Affiliated Hospital of Anhui Medical University,Hefei 230032,China);Status of studying antituberculosis drug-induced hepatotoxicity and its existing problems[J];Anhui Medical and Pharmaceutical Journal;2008-04
3 LI Yu-Hong1,2, HE Yi-Fu1,2, WANG Feng-Hua1,2, LIN Xu-Bin1,2, XIA Zhong-Jun1,2, SUN Xiao-Fei1,2, LIN Tong-Yu1,2, HUANG Hui-Qiang1,2, ZHANG Li1,2, XU Rui-Hua1,2, JIANG Wen-Qi1,2, GUAN Zhong-Zhen1,2 1. State Key Laboratory of Oncology in Southern China, Guangzhou, Guangdong, 510060, P. R. China 2. Department of Medical Oncology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P. R. China;Clinical Analysis of Liver Damage of 116 Malignant Lymphoma Patients with Chronic HBV Infection after Cytotoxic Chemotherapy[J];Chinese Journal of Cancer;2005-12
4 Miu Ximin Zhang Liang Second Hospital Affiliated to Zhejiang Chinese Medical University,Hangzhou(310053);Clinical Research on Chronic Hepatitis B YMDD Variance and TCM Types[J];Journal of Zhejiang University of Traditional Chinese Medicine;2007-06
5 XU Gan.State food and drug administration,licensed pharmacist qualification authentication center;Beijing,100810;Analysis and comments on the cases associated with "obtaining prescription drugs without prescription recipe"[J];The Journal of Law and Medicine;2005-03
6 TENG Guang-ju,ZOU Zheng-sheng,LI Bao-sen.The Fourth Department of Infectious Diseases,the 302 Hospital of Chinese People's Liberation Army,Beijing 100039,China;The application of genechip in viral hepatitis research[J];International Journal of Epidemiology and Infectious Disease;2006-03
7 Feng Jing-hua, Yin Feng-ming, Yan Zhen-qiu(PLA No.169 Hospital, Hengyang 421002, China);Influence of Proteinic Malnutrition on Hepatitis Induced by Antituberculous Drugs[J];Clinical Journal of Medical Officer;2007-02
8 HE Yi-fu WANG Feng-hua LI Yu-hong (State Key Laboratory of Oncology in Southern China,Guangzhou 510060);The role of prophylactic lamivudine on chronic hepatitis B in HBV carriers with lymphoma after chemotherapy.[J];Chinese Journal of Clinical Hepatology;2006-06
9 YAN Shuang-huan,ZHANG Xin-yuan,CAO Zhi-chen,et al.(The Fifth Hospital of Shijiazhuang,Hebei 050021,China);Relationship between the Antiviral Effect and Changes of Th1/Th2 during the Treatment of Chronic Hepatitis B Using Lamivudine.[J];Chinese Journal of Clinical Hepatology;2009-03
10 ;拉米夫定治疗慢性乙型肝炎患者的疗效观察及护理[J];Journal of Clinical Nursing;2005-06
China Proceedings of conference Full-text Database 1 Hits
1 YAN Taol,WANG Hui-fenl,LI Kel,ZHANG Ai-min2.1.The 13th department of 302 hospital of PLA, Beijing,100039,China.2.The 14th department of 302 hospital of PLA,Beijing,100039,China.;Clinical study for consensus interferon-αtreating chronic HBV-infected patients[A];[C];2009
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 YAO Guang-bi, CUI Zhen-yu, YAO Ji-lu, ZHANG Ding-feng, J! Na-xin, HUANG Ying. Shanghai Jing'an Qu Central Hospital, Shanghai 200040, China;Chronic hepatitis B treated with domestic manufactured lamivudine in 2 200 patients: a phase IV study[J];Chinese Journal of Hepatology;2003-02
2 YAO Guang-bi *, WANG Bao-en, CUI Zhen-yu, YAO Ji-lu, ZENG Min-de. *Shanghai Jing An Qu Central Hospital,Shanghai 200040, China;The long-term efficacy of lamivudine in chronic hepatitis B:interim analysis of 3-year's clinical course[J];Chinese Journal of Internal Medicine;2003-06
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved